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Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB4918
  • Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB4918

Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB4918

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貨號: PAB4918
品牌: Abnova
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  • 詳情
  • 使用說明
  • 常見問題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1.
      • Immunogen:
      • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S473 of human AKT1.
      • Host:
      • Rabbit
      • Reactivity:
      • Human
      • Form:
      • Liquid
      • Purification:
      • Protein A purification
      • Recommend Usage:
      • ELISA (1:1000)Dot Blot (1:500)The optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS (0.09% sodium azide)
      • Storage Instruction:
      • Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Publication Reference
      • 1.
      • Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer.Liao Y, Grobholz R, Abel U, Trojan L, Michel MS, Angel P, Mayer D.Int J Cancer. 2003 Nov 20;107(4):676-80.
      • 2.
      • Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.Powell DJ, Hajduch E, Kular G, Hundal HS.Mol Cell Biol. 2003 Nov;23(21):7794-808.
      • 3.
      • Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.Debnath J, Walker SJ, Brugge JS.J Cell Biol. 2003 Oct 27;163(2):315-26. Epub 2003 Oct 20.
      • Applications
      • Enzyme-linked Immunoabsorbent Assay
      • Dot Blot (Peptide)
      • Dot Blot (Peptide)
      • Dot blot analysis of AKT1 (phospho S473) polyclonal antibody (Cat # PAB4918) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.
      • Application Image
      • Enzyme-linked Immunoabsorbent Assay
      • Dot Blot (Peptide)
      • Dot Blot (Peptide)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 207
      • Protein Accession#:
      • NP_001014431;P31749
      • Gene Name:
      • AKT1
      • Gene Alias:
      • AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA
      • Gene Description:
      • v-akt murine thymoma viral oncogene homolog 1
      • Omim ID:
      • 164730, 181500
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
      • Other Designations:
      • RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase alpha
      • Interactome
      • Interactome
      • Gene Pathway
      • Acute myeloid leukemia
      • Adipocytokine signaling pathway
      • Apoptosis
      • B cell receptor signaling pathway
      • Chemokine signaling pathway
      • Chronic myeloid leukemia
      • Colorectal cancer
      • Endometrial cancer
      • ErbB signaling pathway
      • Fc epsilon RI signaling pathway
      • Fc gamma R-mediated phagocytosis
      • Focal adhesion
      • Glioma
      • Insulin signaling pathway
      • Jak-STAT signaling pathway
      • MAPK signaling pathway
      • Melanoma
      • mTOR signaling pathway
      • Neurotrophin signaling pathway
      • Non-small cell lung cancer
      • Pancreatic cancer
      • Pathways in cancer
      • Prostate cancer
      • Renal cell carcinoma
      • Small cell lung cancer
      • T cell receptor signaling pathway
      • Tight junction
      • Toll-like receptor signaling pathway
      • VEGF signaling pathway
      • Related Disease
      • Adenocarcinoma
      • Adenocarcinoma, Papillary
      • Alzheimer Disease
      • Alzheimer disease
      • Amphetamine-Related Disorders
      • Atherosclerosis
      • Basal Ganglia Diseases
      • Bipolar Disorder
      • Breast Neoplasms
      • Calcinosis
      • Carcinoma
      • Carcinoma, Non-Small-Cell Lung
      • Carcinoma, Papillary
      • Carcinoma, Papillary, Follicular
      • Cardiovascular Diseases
      • Cognition
      • Colonic Neoplasms
      • Colorectal Neoplasms
      • Coronary Artery Disease
          • ... see more
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