Immunogen | RecombinantproteincorrespondingtotheextracellulardomainofhumanVE-Cadherin. |
Epitope | Extracellulardomain. |
Clone | BV9 |
Host | Mouse |
Specificity | ThisantibodyrecognizestheextracellulardomainofVE-Cadherin. |
Isotype | IgG2aκ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Functioningasaclassiccadherinbyimpartingtocellstheabilitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
GeneSymbol | |
PurificationMethod | ProteinGPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton.ActsinconcertwithKRIT1toestablishandmaintaincorrectendothelialcellpolarityandvascularlumen.TheseeffectsaremediatedbyrecruitmentandactivationoftheParpolaritycomplexandRAP1B.RequiredforactivationofPRKCZandforthelocalizationofphosphorylatedPRKCZ,PARD3,TIAM1andRAP1Btothecelljunction.
SUBUNITSTRUCTURE:Interactsviacadherin5domainwithPTPRB.InteractswithTRPC4.InteractswithKRIT1.
SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:Foundatcell-cellboundariesandprobablyatcell-matrixboundaries.KRIT1andCDH5reciprocallyregulatetheirlocalizationtoendothelialcell-celljunctions. |
MolecularWeight | 88kDacalculated |