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Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg
  • Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg

Millipore/MABS191 | Anti-phospho-VEGFR2 (Tyr1212) Antibody, clone 12A10.1/MABS191/100 µg

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貨號: MABS191
品牌: Millipore
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    • Description
      CatalogueNumberMABS191
      DescriptionAnti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1
      AlternateNames
      • Vascularendothelialgrowthfactorreceptor2
      • VEGFR-2
      • Fetalliverkinase1
      • FLK-1
      • Kinaseinsertdomainreceptor
      • KDR
      • Protein-tyrosinekinasereceptorflk-1
      • CD309
      BackgroundInformationKDR/Flk-1/VEGFR-2isaputativereceptorproteintyrosinekinaseexpressedinendothelialcellsofthedevelopingembryo.Vascularendothelialgrowthfactor(VEGF)andVEGFR2havebeenimplicatedasthekeyendothelialcell-specificfactorsignalingpathwayrequiredforpathologicalangiogenesis,includingtumorneovascularization.InhibitionoftheVEGFtyrosinekinasesignalingpathwayblocksnewbloodvesselformationingrowingtumors,leADIngtostasisorregressionoftumorgrowth.
      ProductInformation
      FormatPurified
      Control
      • UntreatedandColony-stimulatingfactor(CSF)treatedPorcineAorticEndothelial(PAE)celllysatesexpressingVEGFR2.
      PresentationPurifiedmousemonoclonalIgMκinbuffercontainingPBSwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationThisAnti-phospho-VEGFR2(Tyr1212)Antibody,clone12A10.1isvalidatedforuseinWBforthedetectionofphospho-VEGFR2(Tyr1212).
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanVEGFR2phosphorylatedatTyr1212.
      EpitopePhosphorylatedTyr1212
      Clone12A10.1
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyrecognizesVEGFR2phosphorylatedatTyr1212.
      IsotypeIgMκ
      SpeciesReactivity
      • Pig
      • Human
      SpeciesReactivityNoteDemonstratedtoreactwithPorcine.PredictedtoreactwithHumanbasedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryVascularendothelialgrowthfactor(VEGF)isamajorgrowthfactorforendothelialcells.ThisgeneencodesoneofthetworeceptorsoftheVEGF.Thisreceptor,knownaskinaseinsertdomainreceptor,isatypeIIIreceptortyrosinekinase.ItfunctionsasthemainmediatorofVEGF-inducedendothelialproliferation,survival,migration,tubularmorphogenesisandsprouting.Thesignallingandtraffickingofthisreceptorareregulatedbymultiplefactors,includingRabGTPase,P2Ypurinenucleotidereceptor,integrinalphaVbeta3,T-cellproteintyrosinephosphatase,etc..Mutationsofthisgeneareimplicatedininfantilecapillaryhemangiomas.
      GeneSymbol
      • KDR
      • FLK1
      • VEGFR2
      Modifications
      • Phosphorylation
      PurificationMethodPurifiedionexchangechromatography
      UniProtNumber
      UniProtSummaryFUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforVEGFA,VEGFCandVEGFD.Playsanessentialroleintheregulationofangiogenesis,vasculardevelopment,vascularpermeABIlity,andembryonichaematopoiesis.Promotesproliferation,survival,migrationanddifferentiationofendothelialcells.PromotesreorganizationoftheactinCytoskeleton.Isoformslackingatransmembranedomain,suchasisoform2andisoform3,mayfunctionasdecoyreceptorsforVEGFA,VEGFCand/orVEGFD.Isoform2playsanimportantroleasnegativeregulatorofVEGFA-andVEGFC-mediatedlymphangiogenesisbylimitingtheamountoffreeVEGFAand/orVEGFCandpreventingtheirbindingtoFLT4.ModulatesFLT1andFLT4signalingbyformingheterodimers.Bindingofvasculargrowthfactorstoisoform1leadstotheactivationofseveralsignalingcascades.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphateandtheactivationofproteinkinaseC.MediatesactivationofMAPK1/ERK2,MAPK3/ERK1andtheMAPkinasesignalingpathway,aswellasoftheAKT1signalingpathway.MediatesphosphorylationofPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,reorganizationoftheactincytoskeletonandactivationofPTK2/FAK1.RequiredforVEGFA-mediatedinductionofNOS2andNOS3,leadingtotheproductionofthesignalingmoleculenitricoxide(NO)byendothelialcells.PhosphorylatesPLCG1.PromotesphosphorylationofFYN,NCK1,NOS3,PIK3R1,PTK2/FAKandSRC.

      CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

      ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofVEGFA,VEGFCorVEGFDleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.InhibitedbythesmallmoleculePTKinhibitorSU5614((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one).

      SUBUNITSTRUCTURE:InteractswithMYOF.InteractswithVEGFA,VEGFCandVEGFD.MonomerintheabsenceofboundVEGFA,VEGFCorVEGFD.HomodimerinthepresenceofbounddimericVEGFA,VEGFCorVEGFD.CanalsoformheterodimerswithFLT1andFLT4.Interacts(tyrosinephosphorylated)withFYN,NCK1,PLCG1andSHB.InteractswithHIV-1Tat.InteractswithCBL.InteractswithSH2D2A/TSADandGRB2.

      SUBCELLULARLOCATION:Isoform1:Cellmembrane;Single-passtypeImembraneprotein.Cytoplasm.Nucleus.Cytoplasmicvesicle.Earlyendosome.Note:Detectedoncaveolae-enrichedlipidraftsatthecellsurface.Isrecycledfromtheplasmamembranetoendosomesandbackagain.PhosphorylationtriggeredbyVEGFAbindingpromotesinternalizationandsubsequentdegradation.VEGFAbindingtriggersinternalizationandtranslocationtothenucleus.Isoforms2and3aresecreted.

      TISSUESPECIFICITY:Detectedincornea(atproteinlevel).Widelyexpressed.
      MolecularWeight~230kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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