UniProtSummary | FUNCTION:Phosphorylatesmicrotubule-associatedprotein2(MAP2).MaypromoteentryinthecellcycleBysimilarity. CATALYTICACTIVITY:ATP+aprotein=ADP+aphosphoprotein. COFACTOR:MagnesiumBysimilarity. ENZYMEREGULATION:ActivatedbythreonineandtyrosinephosphorylationBysimilarity. TISSUESPECIFICITYHighestexpressionintheskeletalmuscle,followedbythebrain.Alsofoundinheart,placenta,lung,liver,pancreas,kidneyandskinfibroblasts. DOMAIN:TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-626andTyr-628,whichactivatestheenzymeBysimilarity. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily. Contains1proteinkinasedomain. |