BackgroundInformation | AmyloidPrecursorProtein(APP)isexpressedinthebrain,kidney,heart,andspleenoffetaltissues;itisinducedduringneuronaldifferentiation.Themost-substantiatedroleforAPPisinsynapticformationandrepair;itsexpressionisupregulatedduringneuronaldifferentiationandafterneuralinjury.Inadultbrain,highestexpressionofAPPisfoundinthefrontallobeofthecortex.Moderateexpressionisobservedinthecerebellarcortex,theposteriorperisylviancortex-operculargyriandthetemporalassociatedcortex.DefectsinAPPareacauseofautosomaldominantAlzheimer"sdisease(AD).UPonintracerebroventricularinjectionofthisantibody,AbetalevelssignificantlydecreasedinthebrainofAPPPS1mousemodelofAD.Arelatedantibody,Cat.No.MABN380,Anti-APP-C99,clonemC99(70-80)wasraisedagainstaslightlydifferentregionofthesameAPP-C99protein. |