BackgroundInformation | ThisantibodydetectshistoneH1andnuclesomalcoreproteinshistonesH2a,H2b,H3,H4.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. HistoneH1isanuclearproteinnecessaryforcondensationofnucleosomechainsintohigherorderstructures. |