BackgroundInformation | Adenomatouspolyposiscoliprotein(APC)isaubiquitousmultidomainproteinthathasawelldocumentedroleasatumorsuppressor.ThemechanismofAPC-mediatedtumorsuppressionisstillanareaofactiveinvestigation;however,severalstudiessuggestthatAPCisanegativeregulatoroftheWntsignalingpathwayasitdownregulatesβ-cateninviainteractionswithAxin/GSK3-βcomplex,therebypreventingtranscriptionofgenessuchasMYCthatcontributetocellproliferation.DefectiveAPCproteinscontributetotheinitiationandproliferationofvarioustypesofcancers,includingfamilialadenomatouspolyposis.However,otherstudieshaveshownthatAPCinteractswitharangeofotherproteinssuchastheEB1microtubule-bindingproteins,toregulateotherprocessessuchascellmigration. |