BackgroundInformation | TorsinAcanregulatethecellulartraffickingofthedopaminetransporter,aswellasotherpolytopicmembrane-boundproteins,includingGprotein-coupledreceptors,transporters,andionchannels.TorsinAisfoundinthedopamineneuronsthatarelostinPD,andisacomponentofLewybodies.inaddition,ageneticdefectinTorsinAunderliesTorsiondystonia,adiseasecharacterizedbypainfulmusclecontractionsthatresultinuncontrollabledistortions. |