UniProtSummary | FUNCTION:Mediatestheuptakeofglutamateintosynapticvesiclesatpresynapticnerveterminalsofexcitatoryneuralcells.Mayalsoplayaroleintheendocrineglutamatergicsystemofothertissuessuchaspinealglandandpancreas.Mayalsomediatethetransportofinorganicphosphate.
SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane.Membrane;Multi-passmembraneprotein(Potential).Celljunction,synapse,synaptosome.
TISSUESPECIFICITY:Expressedinbrain(atproteinlevel).Expressedinbrainstem,deepnuclei,septalnuclei,nucleiofthediagonalband,frontalcortex,hypothalamus,midbrain,parietalcortexandtemporalcortex.AlsoexpressedinpinealglandandisletsofLangerhans.
SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sodium/anioncotransporterfamily.VGLUTsubfamily.
SIZE:582aminoacids;64392Da |