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Millipore/MAB5384A4 | Anti-NG2 Antibody, clone 132.39, Alexa Fluor?488 Conjugate/MAB5384A4/100 µL
  • Millipore/MAB5384A4 | Anti-NG2 Antibody, clone 132.39, Alexa Fluor?488 Conjugate/MAB5384A4/100 µL

Millipore/MAB5384A4 | Anti-NG2 Antibody, clone 132.39, Alexa Fluor?488 Conjugate/MAB5384A4/100 µL

價格: ￥4812.00 市場價: 8020.00
貨號: MAB5384A4
品牌: Millipore
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    • Description
      CatalogueNumberMAB5384A4
      DescriptionAnti-NG2Antibody,clone132.39,AlexaFluor?488Conjugate
      AlternateNames
      • Chondroitinsulfateproteoglycan4
      • ChondroitinsulfateproteoglycanNG2
      • HSNtumor-specificantigen
      BackgroundInformationNG2isahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor.
      ProductInformation
      FormatAlexaFluor?488
      Control
      • Ratoligodendrocyteprecursorcells
      PresentationPurifiedmousemonoclonalIgG1conjugatedtoAlexaFluor?488inPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationAnti-NG2Antibody,clone132.39,AlexaFluor?488ConjugatedetectslevelofNG2&hasbeenpublished&validatedforuseinICC.
      KeyApplications
      • Immunocytochemistry
      BIOLOGicalInformation
      ImmunogenCelllineexpressingatruncatedformofNG2
      Clone132.39
      HostMouse
      SpecificityThisantibodyrecognizesthenative,recombinant,andproteinfromcellswhichexpressNG2.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithRat.ExpectedtoreactwithMouseandHumanbasedonsequencesimilarty.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryExtracellularmatrixproteinsecretedbymanycelltypes;memberofthelargechondroitinsulfateproteoglycan(CSPG)family;maybeinvolvedwithangiogenesis-dependentprocessessuchaswoundhealingortumorgrowth[RGD].
      GeneSymbol
      • Cspg4
      • Ng2
      • NG2
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsABIlitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreADIngbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.

      SIZE:2326aminoacids;251909Da

      SUBUNIT:InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16(Bysimilarity).InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein;Extracellularside.Apicalcellmembrane;Single-passtypeImembraneprotein;Extracellularside.Cellprojection?lamellipodiummembrane;Single-passtypeImembraneprotein;Extracellularside.Note=Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Afractionmayundergocellsurfaceproteolysisandsecretion.

      TISSUESPECIFICITY:Neuralcellsandalsoextraneuraltissues,especiallyinthedevelopingmesenchyme.

      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation.InvolvedininteractionwithMMP16andITGA4.PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility.

      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.
      MolecularWeightTheunconjugatedparentantibody(Cat.No.MAB5384)hasanobservedmolecularweightat~280kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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