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Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg
  • Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg

Millipore/MAB5352 | Anti-Notch 1 Antibody, clone mN1A/MAB5352/100 µg

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貨號(hào): MAB5352
品牌: Millipore
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    • Description
      CatalogueNumberMAB5352
      Replaces04-1046
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Notch1Antibody,clonemN1A
      BackgroundInformationNotch1consistsofthreedomains.Theextracellulardomaincontaining36epidermalgrowthfactor(EGF)repeatsand3lin-12/Notchrepeats(LNR)andfunctionsasareceptorincell-cellinteractions.Thereisasingletransmembranedomain(TM).Theintracellulardomaincontainssixcdc10/ankyrinrepeats(cdc10)andthenewlydefinedNotchcytokineresponse(NCR)region,whichcontainsaputativebipartiteNLS(nuclearlocalizationsignal).
      ProductInformation
      FormatPurified
      Control
      • Infetaltissues,usespleen,brainstemandlung.Inmostadulttissues,uselymphoidtissues.
      PresentationPurifiedimmunoglobulin.Liquid.
      StorageandShippingInformation
      StorageConditionsMaintainfor1yearat2–8°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationAnti-Notch1Antibody,clonemN1AisahighqualityMouseMonoclonalAntibodyforthedetectionofNotch1&hasbeenvalidatedinICC,IHC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesWesternblotusingECL

      Immunohistochemistry

      Immunocytochemistry

      Immunoprecipitation

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenCdc10-NCRregionofmouseNotch1expressedasaGSTfusionprotein.
      ClonemN1A
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityRecognizesNotch1,intracellulardomain.Theantibodyhasahighaffinityforthe"activated"intracellularformofNotch1,butalowaffinityforthefull-length(unprocessedorheterodimericcellsurface)forms.NoreactivitywithNotch2,3or4.
      IsotypeIgG1
      SpeciesReactivity
      • Mouse
      • Rat
      • Feline
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
      GeneSymbol
      • NOTCH1
      • notch1
      • hN1
      • TAN1
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).
      SIZE:2556aminoacids;272500Da
      SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).
      TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
      PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity).
      DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
      SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
      MolecularWeight272.5kDa(also230kDaprocessedform)
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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