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Millipore/MAB3442 | Anti-von Willebrand Factor Antibody, clone 21-43/MAB3442/500 µL
  • Millipore/MAB3442 | Anti-von Willebrand Factor Antibody, clone 21-43/MAB3442/500 µL

Millipore/MAB3442 | Anti-von Willebrand Factor Antibody, clone 21-43/MAB3442/500 µL

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貨號: MAB3442
品牌: Millipore
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    • Description
      CatalogueNumberMAB3442
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-vonWillebrandFactorAntibody,clone21-43
      AlternateNames
      • FactorVIII-relatedAntigen
      BackgroundInformationvonWillebrandFactorissynthesizedbyendothelialcells,causingadhesionofplateletstoinjuredvesselwallsandfunctionsasacarrierandstABIlizerforcoagulationofFactorVIII.ItisoneofthemostwidelyusedendothelialcellMarkersforstudyingangiogenesis/neovascularization.
      ProductInformation
      FormatPurified
      Control
      • Tonsil
      PresentationPurifiedmousemonoclonalIgG1inbuffercontaining0.5mLphosphatebufferedsaline,pH7.4containing0.1%sodiumazideand0.2%bovineserumalbumin,diluted50%v/vwithglycerol.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8oCfromdateofreceipt.
      Forprolongedperiods,storeat-15oCto-20oC.Atthistemperaturetheglycerolsolutionwillnotfreeze.
      Applications
      ApplicationAnti-vonWillebrandFactorAntibody,clone21-43isanantibodyagainstvonWillebrandFactorforuseinELISA,IC,IF,IH,IH(P)&WB.
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • Immunofluorescence
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesApreviouslotoftheantibodywasusedfor:IH,IH(P)IC,ELISA.
      DetectingcarrierstatusandtodistinguishheterogeneityofhaemophiliaandvonWillebrand"sdiseasepatients.

      QuanitifyingthelevelsofvonWillebrandFactorinplasmabysandwichimmunoassay(Francis,1984,1985;Exner,1984).ImprovingpurificationofFactorVIII.
      Identifyingavarietyofvasculartumourssuchashaemangiomas,haemangiosarcomasandKaposi"ssarcoma.
      Theantibodyissuitableforusewithfrozenandformalinfixedtissuesections.

      Indirectimmunoperoxidasestaining-thefinaldilutionwilldependontheassayconditionsanddetectionsystememployed.However,adilutionofatleast1:50willbeapplicabletomostcommonlyusedsystems.

      Theantibodymaybeusedfor:

      -DetectingcarrierstatusandtodistinguishheterogeneityofhaemophiliaandvonWillebrand"sdiseasepatients.

      -QuanitifyingthelevelsofvonWillebrandFactorinplasmabysandwichimmunoassay(Francis,1984,1985;Exner,1984).

      -ImprovingpurificationofFactorVIII.

      -Identifyingavarietyofvasculartumourssuchashaemangiomas,haemangiosarcomasandKaposi"ssarcoma.

      Theantibodyissuitableforusewithfrozenandformalinfixedtissuesections.

      SUGGESTEDUSAGE

      Indirectimmunoperoxidasestaining-thefinaldilutionwilldependontheassayconditionsanddetectionsystememployed.However,adilutionofatleast1:50willbeapplicabletomostcommonlyusedsystems.
      BIOLOGicalInformation
      ImmunogenPurifiedHumanFactorVIIIcomplex
      Clone21-43
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyreactsstronglywithhumanvonWillebrandFactororFactorVIIIRelatedAntigeninbothplasma,usingRIAorELISA,andintissuesbyimmunofluorescenceorimmunoperoxidasestaining.pI:6.55
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheglycoproteinencodedbythisgenefunctionsasbothanantihemophilicfactorcarrierandaplatelet-vesselwallmediatorinthebloodcoagulationsystem.Itiscrucialtothehemostasisprocess.MutationsinthisgeneordeficienciesinthisproteinresultinvonWillebrand"sdisease.Anunprocessedpseudogenehasbeenfoundonchromosome22.
      GeneSymbol
      • VWF
      • F8VWF
      • F8
      • vWF
      • VWD
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P04275#Importantinthemaintenanceofhemostasis,itpromotesadhesionofplateletstothesitesofvascularinjurybyformingamolecularbridgebetweensub-endothelialcollagenmatrixandplatelet-surfacereceptorcomplexGPIb-IX-V.AlsoactsasachaperoneforcoagulationfactorVIII,deliveringittothesiteofinjury,stabilizingitsheterodimericstructureandprotectingitfromprematureclearancefromplasma.
      SIZE:2813aminoacids;309299Da
      SUBUNIT:Multimeric.InteractswithF8.
      SUBCELLULARLOCATION:Secreted.Note=Localizedtostoragegranules.
      TISSUESPECIFICITY:Plasma.
      DOMAIN:SwissProt:P04275ThevonWillebrandantigen2isrequiredformultimerizationofVWFandforitstargetingtostoragegranules.
      PTM:Allcysteineresiduesareinvolvedinintrachainorinterchaindisulfidebonds.
      DISEASE:SwissProt:P04275#DefectsinVWFareassociatedwithvariousformsofvonWillebranddisease(VWD)[MIM:193400,277480].VWDischaracterizedbyfrequentbleeding(gingival,minorskinquantitativelacerations,menorrhagia,etc.).TypeIVWDisassociatedwithadeficiencyofVWF;typeIIbynormaltodecreasedplasmalevelofVWF;typeIIIbyavirtualabsenceofVWF.Therearesubtypes(AtoH)oftypeIIVWD;forexample:typeIIAischaracterizedbytheabsenceofVWFhighmolecularweightmultimersinplasma.
      SIMILARITY:Contains1CTCK(C-terminalcystineknot-like)domain.&Contains4TIL(trypsininhibitory-like)domains.&Contains3VWFAdomains.&Contains3VWFCdomains.&Contains4VWFDdomains.
      MolecularWeight310kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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