Immunogen | Purifiedvimentinfrompigeyelens |
Clone | V9 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | Recognizesa57-60kDaprotein.ShowsnocrossreactivitywithothercloselyrelatedintermediatefilamentproteinsincludingdesminandGFAP.Intissuesections,thisreagentshowspositivereactiononconnectivetissue,endothelialcells,vascularsmoothmusclecellsandastrocytes.Intissueculture,typicalintermediatefilamentprofilesareseeninfibroblastsandothercelltypes,whichcontainvimentin |
Isotype | IgG1 |
SpeciesReactivity | - Bovine
- Canine
- Chicken
- Feline
- Human
- Monkey
- Pig
- Rat
|
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | AlongwiththeMICROFILaments(actins)andmicrotubules(tubulins),theintermediatefilamentsrepresentathirdclassofwell-characterizedcytoskeletalelements.Thesubunitsdisplayatissue-specificpatternofexpression.Desmin(MIM125660)isthesubunitspecificformuscleandvimentinthesubunitspecificformesenchymaltissue.[suppliedbyOMIM] |
GeneSymbol | |
Non-ReactiveSpecies | |
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P08670#Vimentinsareclass-IIIintermediatefilamentsfoundinvariousnon-epithelialcells,especiallymesenchymalcells. SIZE:466aminoacids;53652Da SUBUNIT:Homopolymer.ComponentofacomplexcomposedatleastofACTB,AP2M1,AP2A1,AP2A2,MEGF10andVIM.InteractswithHCVcoreprotein. TISSUESPECIFICITY:Highlyexpressedinfibroblasts,someexpressioninT-andB-lymphocytes,andlittleornoexpressioninBurkitt"slymphomacelllines.Expressedinmanyhormone-independentmammarycarcinomacelllines. PTM:Oneofthemostprominentphosphoproteinsinvariouscellsofmesenchymalorigin.Phosphorylationisenhancedduringcelldivision,atwhichtimevimentinfilamentsaresignificantlyreorganized. SIMILARITY:SwissProt:P08670##Belongstotheintermediatefilamentfamily.... |
MolecularWeight | 57-60kDa |