Specificity | Recognizesanepitopecommontosilaogangliosidesandsulfatidesfromtheplasmamembranesofneurons,andneuroendocrineandglialcells.Anti-A2B5hasbeenusedtospecificallystain:
Neurofibrillarytanglesinthepost-mortembraintissueofpatientswithaconfirmeddiagnosisofAlzheimer"sdisease(Majochaetal.,1989) Neuronsofchickenretina,brain,spinalcord,anddorsalrootganglia(Schnitzer&Schachner,1982;Eisenbarthetal.,1979). Ratstriatalnerveterminals[synaptosomes(Wolf&Kapatos,1989)]. Neuroblastomacellsinman(Oppedaletal.,1989;Coakhametal.,1985). Ratinsulinomacellsandpancreaticisletscells(Shimizuetal.,1983;Bartholomeuszetal.,1989). Humanandratthymicepithelialcells(Haynesetal.,1988). Cellsinvolvedingliogenesis(Bottensteinetal.,1988;Suzumura&Slerberg,1989). Oligodendrocytesandastrocytes,typeII(Dubois-Dalcqetal.,1990). |