當(dāng)前位置 ： Millipore >>> Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg
Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg
  • Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg

Millipore/MAB1407P | Anti-Macrophages/Granulocytes Antibody, clone OX-41/MAB1407P/100 µg

價格: 試用 市場價: 0.00
貨號: MAB1407P
品牌: Millipore
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產(chǎn)品：無質(zhì)量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯(lián)系客服核對商品價格，訂單生效后再付款。
資深產(chǎn)品顧問
咨詢顧問

全國免費服務(wù)熱線

4000-520-616

  • 自營商城 一站式服務(wù)
  • 廠家直采 剔除溢價
  • 品質(zhì)甄選 正品保證
  • 嚴(yán)控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
    • Description
      CatalogueNumberMAB1407P
      ReplacesMAB1407
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Macrophages/GranulocytesAntibody,cloneOX-41
      AlternateNames
      • CD172antigen-likefamilymemberA
      • CD172aantigen
      • InhibitoryreceptorSHPS-1
      • Macrophagefusionreceptor
      • MyD-1antigen
      • SHPsubstrate1
      • SHPsubstrate-1
      • Signal-regulatoryproteinalpha-1
      • signal-regulatoryproteinalpha
      BackgroundInformationMacrophagesandgranulocytesexpressSignalregulatoryprotein(SIRP),whichisatransmembraneglycoproteininvolvedinthedownregulationoftyrosinekinasereceptorsignaltransductioninducedbycelladhesion,growthfactorsorinsulin.Theyareimmunoglobulin-likecellsurfacereceptorforCD47.ByCD47bindingthereisanegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivationthatpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells.
      ProductInformation
      FormatAffinityPurified
      Control
      • Macrophages,monocytes,lymphoidorgans.
      PresentationPurifiedmousemonoclonalIgG2ainbuffercontaining0.09%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8°Cinundilutedaliquotsfromdateofreceipt.
      Applications
      ApplicationThisAnti-Macrophages/GranulocytesAntibody,cloneOX-41isvalidatedforuseinFC,IC,IH,IH(P),WBforthedetectionofMacrophages/Granulocytes.
      KeyApplications
      • FlowCytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:
      FrozensectionsandFormalinfixed,paraffinembeddedtissuesections(requirestrypsinorpronasepre-treatment).

      WesternBlotting:
      Apreviouslotofthisantibodywasusedinwesternblot.

      Flowcytometry:
      1:100-1:200ofapreviouslotwasused.(Use10μLofworkingdilutionfor10^6cellsin100μL).

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenRatperitonealmacrophages.
      CloneOX-41
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityMAB1407PrecognizesratSIRP(Signalregulatoryprotein),whichisexpressedselectivelybymyeloidcellsandbyneurons.ThismonoclonalbindstoadifferentepitopeonSIRPthanED9.ItdoesnotblocktheinteractionofCD172aandCD47.
      Labelsmostmacrophagesincludingresidentperitoneal,alveolarandactivatedmacrophages.Recognitionofothermacrophagesislimitedtoonlyoccasionalkupffercells.Inadditionitlabelsgranulocytesandapopulationofdendriticcells.Italsolabelsbrainextensively.
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteHuman.Expectedtocross-reactwithratandmouse.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberofthesignal-regulatory-protein(SIRP)family,andalsobelongstotheimmunoglobulinsuperfamily.SIRPfamilymembersarereceptor-typetransmembraneglycoproteinsknowntobeinvolvedinthenegativeregulationofreceptortyrosinekinase-coupledsignalingprocesses.Thisproteincanbephosphorylatedbytyrosinekinases.Thephospho-tyrosineresiduesofthisPTPhavebeenshowntorecruitSH2domaincontainingtyrosinephosphatases(PTP),andserveassubstratesofPTPs.Thisproteinwasfoundtoparticipateinsignaltransductionmediatedbyvariousgrowthfactorreceptors.CD47hasbeendemonstratedtobealigandforthisreceptorprotein.ThisgeneanditsproductshareveryhighsimilaritywithseveralothermembersoftheSIRPfamily.Theserelatedgenesarelocatedincloseproximitytoeachotheronchromosome20p13.Multiplealternativelysplicedtranscriptvariantshavebeendeterminedforthisgene.[providedbyRefSeq]
      GeneSymbol
      • CD172a
      • SIRPA
      • SIRPalpha2
      • BIT
      • SHPS1
      • MFR
      • SIRP
      • p84
      • SHPS-1
      • Sirp-alpha-1
      • CD172A
      • Sirp-alpha-2
      • SIRP-ALPHA-1
      • PTPNS1
      • SIRPalpha
      • P84
      • Bit
      • MYD1
      • MYD-1
      PurificationMethodImmunoAffinityPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P78324#Immunoglobulin-likecellsurfacereceptorforCD47.ActsasdockingproteinandinducestranslocationofPTPN6,PTPN11andotherbindingpartnersfromthecytosoltotheplasmamembrane.Supportsadhesionofcerebellarneurons,neuriteoutgrowthandglialcellattachment.Mayplayakeyroleinintracellularsignalingduringsynaptogenesisandinsynapticfunction(Bysimilarity).Involvedinthenegativeregulationofreceptortyrosinekinase-coupledcellularresponsesinducedbycelladhesion,growthfactorsorinsulin.Mediatesnegativeregulationofphagocytosis,mastcellactivationanddendriticcellactivation.CD47bindingpreventsmaturationofimmaturedendriticcellsandinhibitscytokineproductionbymaturedendriticcells.
      SIZE:503aminoacids;54813Da
      SUBUNIT:BindsPTPN11whentyrosine-phosphorylated,exceptinmacrophages,whereitprimarilybindsPTPN6.BindsGRB2invitro.BindsFGR(Bysimilarity).BindsJAK2irrespectiveofitsphosphorylationstatusandformsastablecomplex.BindsSCAP1and/orSCAP2.TheresultingcomplexrecruitsFYB.BindsPTK2B.
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:Ubiquitous.Highlyexpressedinbrain.Detectedonmyeloidcells,butnotT-cells.Detectedatlowerlevelsinheart,placenta,lung,testis,ovary,colon,liver,smallintestine,prostate,spleen,kidney,skeletalmuscleandpancreas.
      PTM:N-glycosylated.&PhosphorylatedontyrosineresiduesinresponsetostimulationwithEGF,growthhormone,insulinandPDGF.DephosphorylatedbyPTPN11.
      SIMILARITY:SwissProt:P78324##Contains2Ig-likeC1-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain
      MolecularWeight56kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    螞蟻淘生物188，秉承螞蟻淘一貫的嚴(yán)謹(jǐn)態(tài)度，由螞蟻淘公司專業(yè)人員負(fù)責(zé)品控、采購、物流、銷售、售后，保障正品優(yōu)質(zhì)。以“快速好省，為科研提供好產(chǎn)品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴(yán)格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產(chǎn)品帶給科研！? 力求給你最優(yōu)質(zhì)的商品。
  • Q：生物188產(chǎn)品正品保障嗎？
    A：生物188質(zhì)量把控人員具有十年的從業(yè)經(jīng)驗，在業(yè)界享有良好的口碑；自營商城，直接從廠家采購， 自己的團隊負(fù)責(zé)國際物流和清關(guān)，中間沒有第三方，所有流程嚴(yán)格把控，100%保證正品，假一罰十。

    Q：下單后可以修改訂單嗎？
    A：下單后的商品付款之前可以修改；訂單付款成功，需要聯(lián)系我們客服進行修改；客服電話：4000-520-616

    Q：可以開發(fā)票嗎？
    A：本網(wǎng)站所售商品都是正規(guī)清關(guān)，均開具16%正規(guī)發(fā)票，發(fā)票金額含配送費金額，另有說明的除外。

    Q：商品幾天可以發(fā)貨？
    A：生物188商品，全部現(xiàn)貨銷售，付款后即可發(fā)貨,一般一周內(nèi)送達！

    Q：如何聯(lián)系商家？
    A：有任何問題夠可以電話咨詢我們，全國24小時免費服務(wù)熱線：4000-520-616 或聯(lián)系我們的在線客服QQ：1570468124

    Q：收到的商品少了/發(fā)錯了怎么辦？
    A：同個訂單購買多個商品可能會分為一個以上包裹發(fā)出，可能不會同時送達，建議查看訂單詳情是否是 部分發(fā)貨狀態(tài)；如未收到，可聯(lián)系在線客服或者致電4000-520-616。

    Q：退換貨/維修需要多長時間？
    A：一般情況下，退貨處理周期為客戶收到產(chǎn)品一個月內(nèi)（以快遞公司顯示簽收時間為準(zhǔn)），包裝規(guī)格、 數(shù)量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內(nèi)申請退換貨；特殊商品以合同條款為準(zhǔn)。

何為188

極簡而嚴(yán)謹(jǐn)，我們僅銷售188款生物醫(yī)學(xué)科研用品，款款都是爆款；因為少所以聚焦，聚焦甄選每一款產(chǎn)品，聚焦服務(wù)每一位客戶!

關(guān)注我們 :

點擊QQ聯(lián)系我們
生物188微信

關(guān)注188微信公眾號

獲取最新優(yōu)惠活動通知

  • 品質(zhì)甄選，正品保證

  • 自營電商，廠家直采

  • 極簡主義，188精品