Specificity | DirectedagainsttheThy1.1antigenicdeterminantwhichisamonomorphicdeterminantwithinratstrainsbutpolymorphicinthemouse(positivetoAKRstrain,negativetoCVAandBALB/c).Thy-1antigenispresentonavarietyofcelltypesincludingthymocytes,neuronalcells,T-lymphocytes(mouse),stemcellsandimmatureBcells(rat)andconnectivetissue(Campbell,1981).Thy-1isaglycoprotein,112aminoacids,whichishomologoustoimmunoglobulindomains(Williams&Gagnon,1982).MAB1406canbecoupledtosepharose4-BandusedtopurifymouseThy-1.1andratThy-1antigens(Campbell,1981;Williams&Gagnon,1982).MAB1406canalsobeusedtostudythekillingofThy-1tumorcellswithantibody-toxinconjugates(Neville,1982). |