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Millipore/IHCR2023-6 | IHC Select? Anti-CD79a Antibody, prediluted, clone JCB117/IHCR2023-6/6 mL
  • Millipore/IHCR2023-6 | IHC Select? Anti-CD79a Antibody, prediluted, clone JCB117/IHCR2023-6/6 mL

Millipore/IHCR2023-6 | IHC Select? Anti-CD79a Antibody, prediluted, clone JCB117/IHCR2023-6/6 mL

價格: ￥2952.00 市場價: 4920.00
貨號: IHCR2023-6
品牌: Millipore
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    • Description
      CatalogueNumberIHCR2023-6
      TradeName
      • IHCSelect
      • Chemicon
      DescriptionIHCSelect?Anti-CD79aAntibody,prediluted,cloneJCB117
      ProductInformation
      FormatPurified
      PresentationMonoclonalmouseantibodysuppliedinliquidformatastissueculturesupernatant,dilutedinPBS,pH7.2withstABIlizers,0.2%Tween20,and0.1%ProClin300aspreservative.
      StorageandShippingInformation
      StorageConditionsMaintainat2-8°C.Refertovialforexpirationdating.
      Applications
      ApplicationThisIHCSelectAnti-CD79aAntibody,prediluted,cloneJCB117isvalidatedforuseinIH(P)forthedetectionofCD79a.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      ApplicationNotesAntibodyispredilutedandreadytouseforImmunohistochemistryofformalin-fixed,paraffin-embeddedtissues.

      Pretreatment:HeatInducedEpitopeRetrieval(HIER).RecommendCitrateBuffer,pH6.0(Cat.No.21545).NosignalwasdetectedwithoutEpitoperetrieval.

      Incubation:10minuteswithIHCSelect?DetectionKits.

      CD79ahasbeenpredilutedforuseastheprimaryantibodywithChemicon"sIHCSelect?DetectionKitsandProtocols(CatalogNos.DAB050,DET-HP1000,APR050,andDET-APR1000),butothersupplier"sIHCdetectionsystemsmaybeused.Foroptimizedprotocoldetails,visitwww.chemicon.comandselecttheprotocolslinkunderCat.No.IHCR2023-6.
      BIOLOGicalInformation
      CloneJCB117
      HostMouse
      SpecificityBcellantigenreceptorcomplex.TheantibodyreactswithcellsinBcellareasinlymphoidtissue,andwithscatteredcellsinmanyothertissues.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheBlymphocyteantigenreceptorisamultimericcomplexthatincludestheantigen-specificcomponent,surfaceimmunoglobulin(Ig).SurfaceIgnon-covalentlyassociateswithtwootherproteins,Ig-alphaandIg-beta,whicharenecessaryforexpressionandfunctionoftheB-cellantigenreceptor.ThisgeneencodestheIg-alphaproteinoftheB-cellantigencomponent.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeendescribed.
      GeneSymbol
      • CD79A
      • MB-1
      • IGA
      • Ig-alpha
      • MB1
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P11912#RequiredincooperationwithCD79BforinitiationofthesignaltransductioncascadeactivatedbybindingofantigentotheB-cellantigenreceptorcomplex(BCR)whichleadstointernalizationofthecomplex,traffickingtolateendosomesandantigenpresentation.AlsorequiredforBCRsurfaceexpressionandforefficientdifferentiationofpro-andpre-B-cells.StimulatesSYKautophosphorylationandactivation.BindstoBLNK,bringingBLNKintoproximitywithSYKandallowingSYKtophosphorylateBLNK.AlsointeractswithandincreasesactivityofsomeSrc-familytyrosinekinases.RepressesBCRsignalingduringdevelopmentofimmatureBcells.
      SIZE:226aminoacids;25038Da
      SUBUNIT:Heterodimerofalphaandbetachains;disulfide-linked.PartoftheB-cellantigenreceptorcomplexwherethealpha/betachainheterodimerisnon-covalentlyassociatedwithanantigen-specificmembrane-boundsurfaceimmunoglobulinoftwoheavychainsandtwolightchains.InteractsthroughitsphosphorylatedITAMdomainwiththeSH2domainsofSYKwhichstimulatesSYKautophosphorylationandactivation.Alsointeracts,whenphosphorylatedonTyr-210,withtheSH2domainofBLNK/SLP65,bringingBLNKintoproximitywithSYKandallowingSYKtophosphorylateBLNKwhichisnecessaryfortraffickingoftheBCRtolateendosomes.InteractswithSrc-familytyrosinekinasesincludingFYNandLYN,increasingtheiractivity(Bysimilarity).
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note=Followingantigenbinding,theBCRhasbeenshowntotranslocatefromdetergent-solubleregionsofthecellmembranetolipidraftsalthoughsignaltransductionthroughthecomplexcanalsooccuroutsidelipidrafts(Bysimilarity).
      TISSUESPECIFICITY:B-cells.
      PTM:Phosphorylatedontyrosine,serineandthreonineresiduesuponB-cellactivation.PhosphorylationoftyrosineresiduesbySrc-familykinasesisanearlyandessentialfeatureoftheBCRsignalingcascade.ThephosphorylatedtyrosinesserveasdockingsitesforSH2-domaincontainingkinases,leADIngtotheiractivationwhichinturnleadstophosphorylationofdownstreamtargets.Phosphorylationofserineandthreonineresiduesmaypreventsubsequenttyrosinephosphorylation.
      DISEASE:SwissProt:P11912#DefectsinCD79Aareacauseofnon-Brutontypeagammaglobulinemia[MIM:601495].AgammaglobulinemiaisanimmunodeficiencydiseasewhichresultsindevelopmentaldefectsinthematurationpathwayofB-cells.Twodifferentmutations,oneatthesplicedonorsiteofintron2andtheotheratthespliceacceptorsiteforexon3,havebeenidentified.Bothmutationsgiverisetoatruncatedprotein.
      SIMILARITY:SwissProt:P11912##Contains1Ig-likeC2-type(immunoglobulin-like)domain.&Contains1ITAMdomain.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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