Immunogen | Gamma-gammaenolasepurifiedfromhumanbrain |
Clone | BBS/NC/VI-H14 |
Host | Mouse |
Specificity | Reactswithhumangamma-gammaenolase(Mr46000).ThisantibodydoesnotcrossreactwithalphaorbetasubunitsofNSE. |
Isotype | IgG1κ |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesoneofthethreeenolaseisoenzymesfoundinmammals.Thisisoenzyme,ahomodimer,isfoundinmatureneuronsandcellsofneuronalorigin.Aswitchfromalphaenolasetogammaenolaseoccursinneuraltissueduringdevelopmentinratsandprimates. |
GeneSymbol | - ENO2
- NSE
- Gamma-enolase
- EC4.2.1.11
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P09104#Hasneurotrophicandneuroprotectivepropertiesonabroadspectrumofcentralnervoussystem(CNS)neurons.Binds,inacalcium-dependentmanner,toculturedneocorticalneuronsandpromotescellsurvival(Bysimilarity). COFACTOR:Magnesium.Requiredforcatalysisandforstabilizingthedimer. SIZE:434aminoacids;47269Da SUBUNIT:Mammalianenolaseiscomposedof3isozymesubunits,alpha,betaandgamma,whichcanformhomodimersorheterodimerswhicharecell-typeanddevelopment-specific. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellmembrane(Bysimilarity).Note=Cantranslocatetotheplasmamembraneineitherthehomodimeric(alpha/alpha)orheterodimeric(alpha/gamma)form(Bysimilarity). TISSUESPECIFICITY:Thealpha/alphahomodimerisexpressedinembryoandinmostadulttissues.Thealpha/betaheterodimerandthebeta/betahomodimerarefoundinstriatedmuscle,andthealpha/gammaheterodimerandthegamma/gammahomodimerinneurons.DEVELOPMENTALSTAGE:Duringontogenesis,thereisatransitionfromthealpha/alphahomodimertothealpha/betaheterodimerinstriatedmusclecells,andtothealpha/gammaheterodimerinnervecells. SIMILARITY:SwissProt:P09104##Belongstotheenolasefamily. |