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Abnova/ACVR1B (Human) Matched Antibody Pair/1kit/H00000091-AP41
  • Abnova/ACVR1B (Human) Matched Antibody Pair/1kit/H00000091-AP41

Abnova/ACVR1B (Human) Matched Antibody Pair/1kit/H00000091-AP41

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貨號(hào): H00000091-AP41
品牌: Abnova
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      • Specification
      • Gene Info
      • Pathway
      • Disease
      • Related Products
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      • Specification
      • Product Description:
      • This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACVR1B.
      • Reactivity:
      • Human
      • Quality Control Testing:
      • Standard curve using recombinant protein ( H00000091-Q01 ) as an analyte.QC Testing of H00000091-AP41Sandwich ELISA detection sensitivity ranging from 10 ng/ml to 100 ng/ml.
      • Supplied Product:
      • Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACVR1B, IgG1 Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACVR1B, IgG1 Kappa (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
      • Storage Instruction:
      • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • ELISA Pair (Recombinant protein)
      • PDF DownloadProtocol Download
      • Application Image
      • ELISA Pair (Recombinant protein)
      • Gene Information
      • Entrez GeneID:
      • 91
      • Gene Name:
      • ACVR1B
      • Gene Alias:
      • ACTRIB,ACVRLK4,ALK4,SKR2
      • Gene Description:
      • activin A receptor, type IB
      • Omim ID:
      • 601300
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
      • Other Designations:
      • activin A receptor, type II-like kinase 4,activin A type IB receptor,activin receptor-like kinase 4,serine(threonine) protein kinase receptor R2
      • Gene Pathway
      • Adherens junction
      • Chronic myeloid leukemia
      • Colorectal cancer
      • Cytokine-cytokine receptor interaction
      • Endocytosis
      • MAPK signaling pathway
      • Pancreatic cancer
      • Pathways in cancer
      • TGF-beta signaling pathway
      • Related Disease
      • Genetic Predisposition to Disease
      • Head and Neck Neoplasms
      • Neoplasm Recurrence, Local
      • Neoplasms, Second Primary
      • Obesity
      • Ovarian Failure, Premature
      • Polycystic Ovary Syndrome
      • Puberty, Delayed
      • Puberty, Precocious
      • Schizophrenia
      • Thrombophilia
      • Tobacco Use Disorder
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