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Millipore/FCMAB404PE | Milli-Mark? Anti-Tie2/TEK-PE Antibody, clone Ab33/FCMAB404PE/100 tests
  • Millipore/FCMAB404PE | Milli-Mark? Anti-Tie2/TEK-PE Antibody, clone Ab33/FCMAB404PE/100 tests

Millipore/FCMAB404PE | Milli-Mark? Anti-Tie2/TEK-PE Antibody, clone Ab33/FCMAB404PE/100 tests

價格: ¥3204.00 市場價: 5340.00

貨號: FCMAB404PE
品牌: Millipore
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    • Description
      CatalogueNumberFCMAB404PE
      TradeName
      • Milli-Mark
      DescriptionMilli-Mark?Anti-Tie2/TEK-PEAntibody,cloneAb33
      AlternateNames
      • Tunicainternaendothelialcellkinase
      • Tyrosine-proteinkinasereceptorTEK
      • Tyrosine-proteinkinasereceptorTIE-2
      • hTIE2
      • p140TEK
      • CD202b
      BackgroundInformationTIE2(tyrosinekinasewithIgandEGFhomologydomains2)isexpressedalmostexclusivelyinendothelialcellsinmice,ratsandhumans.Thisreceptorpossessesauniqueextracellulardomaincontainingtwoimmunoglobulin-likeloopsseparatedbythreeepidermalgrowthfactor-likerepeatsthatareconnectedtothreefibronectintypeIII-likerepeats.TheligandforthereceptorisAngiopoietin1.DefectsinTIE2areassociatedwithinheritedvenousmalformations;theTIE2signalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.
      ProductInformation
      FormatPhycoerythrin
      Control
      • HUVECcells
      PresentationPurifiedmousemonoclonalIgG1kconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationMilli-MarkAnti-Tie2/TEK-PEAntibody,cloneAb33isanantibodyagainstTie2/TEKforuseinFC.
      KeyApplications
      • FlowCytometry
      BIOLOGicalInformation
      ImmunogenFusionproteincorrespondingtoresidues1-745ofhumanTie2/TEKwithaC-terminalHis6-tagpurifiedfrominfectedSF-9cells.
      CloneAb33
      HostMouse
      SpecificityAntibodyrecognizesHumanTie2/TEK.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase.
      GeneSymbol
      • TEK
      • TIE2
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.ItmayconstitutetheearliestmammalianendothelialcelllineageMarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.

      SIZE:1124aminoacids;125811Da

      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.

      TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.

      DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.

      SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain.
      MolecularWeight126kDaCalculated
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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