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Millipore/FCMAB129CP | Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22/FCMAB129CP/100 tests
  • Millipore/FCMAB129CP | Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22/FCMAB129CP/100 tests

Millipore/FCMAB129CP | Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22/FCMAB129CP/100 tests

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貨號(hào): FCMAB129CP
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    • Description
      CatalogueNumberFCMAB129CP
      TradeName
      • Milli-Mark
      DescriptionMilli-MarkAnti-EGFR-PerCPAntibody,cloneLA22
      AlternateNames
      • Receptortyrosine-proteinkinaseErbB-1
        avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog
        cellgrowthinhibitingprotein40
        cellproliferation-inducingprotein61
        epidermalgrowthfactorreceptor
        epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog)
        epidermalgrowthfactorreceptor(erythroblasticleukemiaviral(v-erb-b)oncogenehomolog,avian)
      BackgroundInformationProteinkinasesareenzymesthattransferaphosphategroupfromaphosphatedonorontoanacceptoraminoacidinasubstrateprotein.Bythisbasicmechanism,proteinkinasesmediatemostofthesignaltransductionineukaryoticcells,regulatingcellularmetabolism,transcription,cellcycleprogression,cytoskeletalrearrangementandcellmovement,apoptosis,anddifferentiation.Theproteinkinasefamilyisoneofthelargestfamiliesofproteinsineukaryotes,classifiedin8majorgroupsbasedonsequencecomparisonoftheirtyrosine(PTK)orserine/threonine(STK)kinasecatalyticdomains.EpidermalGrowthfactorreceptor(EGFR)istheprototypememberofthetype1receptortyrosinekinases.EGFRoverexpressionintumorsindicatespoorprognosisandisobservedintumorsoftheheadandneck,brain,bladder,stomach,breast,lung,endometrium,cervix,vulva,ovary,esophagus,stomachandinsquamouscellcarcinoma.
      ProductInformation
      FormatPerCP
      Control
      • A431cells.
      PresentationPurifiedmousemonoclonalIgG2aconjugatedtoPerCPinPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8oCprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationMilli-MarkAnti-EGFR-PerCPAntibody,cloneLA22detectslevelofEGFR&hasbeenpublished&validatedforuseinFC.
      KeyApplications
      • FlowCytometry
      WorkingSolutionCells/testTotalReactionVolume
      5μl5x105Cells/95μlPBS100μl
      10μl1x106Cells/90μlPBS100μl
      BIOLOGicalInformation
      ImmunogenA431membraneproteins
      EpitopeUnknown
      CloneLA22
      HostMouse
      SpecificityRecognizesthesequenceofAla351-Asp364ofhumanEGFreceptor,Mr180kDa,(basedonnumberingwithoutthesignalpeptide)(Wuetal.,1989).
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteTestedandpassedonHuman.basedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq].
      GeneSymbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P00533#Isoform2/truncatedisoformmayactasanantagoNIST.

      SIZE:1210aminoacids;134277Da

      SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.&Isoform2:Secreted.

      TISSUESPECIFICITY:Expressedinplacenta.Isoform2isalsoexpressedinovariancancers.

      PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.&MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur.DISEASE:SwissProt:P00533#DefectsinEGFRareassociatedwithlungcancer[MIM:211980].

      SIMILARITY:SwissProt:P00533##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily.&Contains1proteinkinasedomain.

      MISCELLANEOUS:BindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation
      MolecularWeight180kDaObserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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