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Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests
  • Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

Millipore/FCMAB100P | Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE/FCMAB100P/100 tests

價格: ￥3324.00 市場價: 5540.00
貨號: FCMAB100P
品牌: Millipore
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    • Description
      CatalogueNumberFCMAB100P
      TradeName
      • Milli-Mark
      DescriptionMilli-MarkAnti-Phospho-Erk1/2Antibody(Thr202/Tyr204,Thr185/Tyr187)-PE
      AlternateNames
      • Erk1
        Erk2
        p44-MAPK
        p42-MAPK
        MAPK2
        PRKM2
        p41mapk
        PRKM1
        p44
        ERK2
        P42MAPK
        ERK
        p42
        MAPK1
        ERT1
        ERT2
        Mitogen-activatedproteinkinase
        MAPKinase2
        MAPKianse1
        MAPK
      BackgroundInformationErk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).
      ProductInformation
      FormatPE
      Control
      • JurkatCells
      PresentationPurifiedRabbitmonoclonalsupernatantconjugatedtophycoerythrininbuffercontainingPBSwith0.05%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8°Cfromdateofreceipt.Protectfromlight.
      Applications
      ApplicationThisMilli-MarkPhospho-Erk1/2antibodyisvalidatedforuseinFlow&WBforthedetectionoftheMilli-MarkPhospho-Erk1/2protein.
      KeyApplications
      • FlowCytometry
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenPhosphorylatedrecombinantpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
      EpitopePhosphorylatedThr185/PhosphorylatedTyr187
      CloneAW39R
      HostRabbit
      SpecificityAntibodyrecognizesRecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteTestedandpassedonHuman.basedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
      GeneSymbol
      • Erk1
      • Erk2
      • p44-MAPK
      • p42-MAPK
      • MAPK2
      • PRKM2
      • p41mapk
      • PRKM1
      • p44
      • ERK2
      • P42MAPK
      • ERK
      • p42
      • MAPK1
      • ERT1
      • ERT2
      • Mitogen-activatedproteinkinase
      • MAPKinase2
      • MAPKinase1
      • MAPK
      Modifications
      • Phosphorylation
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
      COFACTOR:Magnesium(Bysimilarity).
      SIZE:360aminoacids;41390Da
      SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
      DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
      MolecularWeight42kDaand44kDaObserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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