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Millipore/CBL412X | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?488 Conjugated/CBL412X/40 µL
  • Millipore/CBL412X | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?488 Conjugated/CBL412X/40 µL

Millipore/CBL412X | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?488 Conjugated/CBL412X/40 µL

價格: ￥4680.00 市場價: 7800.00
貨號: CBL412X
品牌: Millipore
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    • Description
      CatalogueNumberCBL412X
      DescriptionAnti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor?488Conjugated
      AlternateNames
      • Tubulinbeta-4
      • Tubulinbeta-III
      • tubulin,beta3
      • tubulin,beta4
      BackgroundInformationTubulinisoneofseveralmembersofasmallfamilyofglobularproteinswhichpolymerizetoformcytoskeletalstructurescalledmicrotubules.Themostcommonmembersofthetubulinfamilyareα-tubulinandβ-tubulin.Tubulindimers,typicallycomposedofα-andβ-tubulinsubunits,assembleontomicrotubulesforminglargepolymers.β-IIItubulinisauniquemicrotubulesubunitthatisfoundexpressedalmostexclusivelyinneurons.Duetotheuniqueexpressionpatternofβ-IIItubulinitisoftenutilizedasaMarkertoidentifyneuronalcellsfromotherbraincellssuchasgliawhichdonotexpressit.β-IIItubulinalsoservesasacytoarchitecturalmarkersinceitisprimarilyfoundwithinneuriteextensions.
      ProductInformation
      FormatAlexaFluor?488
      Control
      • RatCortexCells.
      PresentationPurifiedimmunoglobulinin0.02MPhosphatebuffer,0.25MNaClcontaining0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8°Cfromdateofreceipt.
      Applications
      ApplicationDetectTubulinβ-IIIusingthisAnti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor?488ConjugatedvalidatedforuseinIC,IF,WB,IH&IP.
      KeyApplications
      • Immunocytochemistry
      • Immunofluorescence
      • WesternBlotting
      • Immunohistochemistry
      • Immunoprecipitation
      ApplicationNotesImmunohistochemistry:5-10μg/mLonfrozenbraintissue.
      AlthoughthisconjugatedantibodywillworkforWesternblottingandImmunoprecipitation,werecommendcatalognumberCBL412iftheseareyourprimaryapplications.
      Optimalworkingconcentrationmustbedeterminedbyenduser.
      BIOLOGicalInformation
      EpitopeC-terminus
      CloneTU-20
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityThisantibodyreactswiththeC-terminusofthebeta-IIIisoformoftubulin,whichisknowntobeneuronspecific.Doesnotidentifybetatubulinfoundinglialcells.
      IsotypeIgG1
      SpeciesReactivity
      • Bovine
      • Human
      • Primate
      • Mouse
      • Pig
      • Rat
      SpeciesReactivityNoteReactswithBovine,Human,Primate,Mouse,Porcine(Pig),andRat.Reactivitywithotherspecieshasnotbeendetermined.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaclassIIImemberofthebetatubulinproteinfamily.Betatubulinsareoneoftwocoreproteinfamilies(alphaandbetatubulins)thatheterodimerizeandassembletoformmicrotubules.Thisproteinisprimarilyexpressedinneuronsandmaybeinvolvedinneurogenesisandaxonguidanceandmaintenance.Mutationsinthisgenearethecauseofcongenitalfibrosisoftheextraocularmusclestype3.Alternatesplicingresultsinmultipletranscriptvariants.Apseudogeneofthisgeneisfoundonchromosome6.[providedbyRefSeq,Oct2010].
      GeneSymbol
      • MC1R
      • TUBB4
      • beta-4
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Tubulinisthemajorconstituentofmicrotubules.ItbindstwomolesofGTP,oneatanexchangeablesiteonthebetachainandoneatanon-exchangeablesiteonthealpha-chain.TUBB3playsacriticalroleinproperaxonguidanceandmantainance.
      SUBUNITSTRUCTURE:Dimerofalphaandbetachains.
      SUBCELLULARLOCATION:Cytoplasm?Cytoskeleton.
      TISSUESPECIFICITY:Expressionisprimarilyrestrictedtocentralandperipheralnervoussystem.Greatlyincreasedexpressioninmostcanceroustissues.
      DOMAIN:ThehighlyacidicC-terminalregionmaybindcationssuchascalcium.
      PTM:SomeglutamateresiduesattheC-terminusarepolyglutamylated.Thismodificationoccursexclusivelyonglutamateresiduesandresultsinpolyglutamatechainsonthegamma-carboxylgroup.AlsomonoglycylatedbutnotpolyglycylatedduetotheabsenceoffunctionalTTLL10inhuman.Monoglycylationismainlylimitedtotubulinincorporatedintoaxonemes(ciliaandflagella)whereasglutamylationisprevalentinneuronalcells,centrioles,axonemes,andthemitoticspindle.Bothmodificationscancoexistonthesameproteinonadjacentresidues,andloweringglycylationlevelsincreasespolyglutamylation,andreciprocally.TheprecisefunctionofsuchmodificationsisstillunclearbuttheyregulatetheassemblyanddynamicsofaxonemalmicrotubulesProbable.
      PhosphorylatedonSer-172byCDK1duringthecellcycle,frommetaphasetotelophase,butnotininterphase.Thisphosphorylationinhibitstubulinincorporationintomicrotubules.
      INVOLVEMENTINDISEASE:DefectsinTUBB3arethecauseofcongenitalfibrosisofextraocularmusclestype3A(CFEOM3A)[MIM:600638].Acongenitalocularmotilitydisordermarkedbyrestrictiveophthalmoplegiaaffectingextraocularmusclesinnervatedbytheoculomotorand/ortrochlearnerves.Itisclinicallycharacterizedbyanchoringoftheeyesindownwardgaze,ptosis,andbackwardtiltofthehead.Congenitalfibrosisofextraocularmusclestype3presentsasanon-progressive,autosomaldominantdisorderwithvariableexpression.Patientsmaybebilaterallyorunilaterallyaffected,andtheiroculo-motilitydefectsrangefromcompleteophthalmoplegia(withtheeyesfixedinahypo-andexotropicposition),tomildasymptomaticrestrictionsofocularmovement.Ptosis,refractiveerror,amblyopia,andcompensatoryheadpositionsareassociatedwiththemoresevereformsofthedisorder.Insomecasestheocularphenotypeisaccompaniedbyadditionalfeaturesincludingdevelopmentaldelay,corpuscallosumagenesis,basalgangliadysmorphism,facialweakness,polyneuropathy.
      SEQUENCESIMILARITIES:Belongstothetubulinfamily.
      MolecularWeight50kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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