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Millipore/CBL412A5 | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?555 Conjugate/CBL412A5/100 µL
  • Millipore/CBL412A5 | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?555 Conjugate/CBL412A5/100 µL

Millipore/CBL412A5 | Anti-Tubulin β-III Antibody, clone TU-20, Alexa Fluor?555 Conjugate/CBL412A5/100 µL

價(jià)格: ￥4680.00 市場價(jià): 7800.00
貨號(hào): CBL412A5
品牌: Millipore
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    • Description
      CatalogueNumberCBL412A5
      DescriptionAnti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor?555Conjugate
      AlternateNames
      • Tubulinbeta-3chain
      • Tubulinbeta-4chain
      • Tubulinbeta-III
      BackgroundInformationTubulinisoneofseveralmembersofasmallfamilyofglobularproteinswhichpolymerizetoformcytoskeletalstructurescalledmicrotubules.Themostcommonmembersofthetubulinfamilyareα-tubulinandβ-tubulin.Tubulindimers,typicallycomposedofα-andβ-tubulinsubunits,assembleontomicrotubulesforminglargepolymers.β-IIItubulinisauniquemicrotubulesubunitthatisfoundexpressedalmostexclusivelyinneurons.Duetotheuniqueexpressionpatternofβ-IIItubulinitisoftenutilizedasaMarkertoidentifyneuronalcellsfromotherbraincellssuchasgliawhichdonotexpressit.β-IIItubulinalsoservesasacytoarchitecturalmarkersinceitisprimarilyfoundwithinneuriteextensions.
      ProductInformation
      FormatAlexaFluor?555
      Control
      • RatE18primarycortexcells
      PresentationPurifiedmousemonoclonalIgG1conjugatedtoAlexaFluor?555inPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationDetectTubulinβ-IIIusingthisAnti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor?555ConjugatevalidatedforuseinICC.
      KeyApplications
      • Immunocytochemistry
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtohumanTubulinβ-III.
      EpitopeC-terminus
      CloneTU-20
      HostMouse
      SpecificityThisantibodyreactswiththeC-terminusofthebeta-IIIisoformoftubulin,whichisknowntobeneuronspecific.Doesnotidentifybetatubulinfoundinglialcells.
      IsotypeIgG1
      SpeciesReactivity
      • Rat
      • Mouse
      • Pig
      • Primate
      • Bovine
      SpeciesReactivityNoteDemonstratedtoreactwithRat.PredictedtoreactwithMouse,Porcine,Primate,andBovinebasedon100%sequencehomology.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaclassIIImemberofthebetatubulinproteinfamily.Betatubulinsareoneoftwocoreproteinfamilies(alphaandbetatubulins)thatheterodimerizeandassembletoformmicrotubules.Thisproteinisprimarilyexpressedinneuronsandmaybeinvolvedinneurogenesisandaxonguidanceandmaintenance.Mutationsinthisgenearethecauseofcongenitalfibrosisoftheextraocularmusclestype3.Alternatesplicingresultsinmultipletranscriptvariants.Apseudogeneofthisgeneisfoundonchromosome6.[providedbyRefSeq,Oct2010].
      GeneSymbol
      • MC1R
      • TUBB4
      • beta-4
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:Tubulinisthemajorconstituentofmicrotubules.ItbindstwomolesofGTP,oneatanexchangeablesiteonthebetachainandoneatanon-exchangeablesiteonthealpha-chain.TUBB3playsacriticalroleinproperaxonguidanceandmantainance.

      SUBUNITSTRUCTURE:Dimerofalphaandbetachains.

      SUBCELLULARLOCATION:Cytoplasm?Cytoskeleton.

      TISSUESPECIFICITY:Expressionisprimarilyrestrictedtocentralandperipheralnervoussystem.Greatlyincreasedexpressioninmostcanceroustissues.

      DOMAIN:ThehighlyacidicC-terminalregionmaybindcationssuchascalcium.

      PTM:SomeglutamateresiduesattheC-terminusarepolyglutamylated.Thismodificationoccursexclusivelyonglutamateresiduesandresultsinpolyglutamatechainsonthegamma-carboxylgroup.AlsomonoglycylatedbutnotpolyglycylatedduetotheabsenceoffunctionalTTLL10inhuman.Monoglycylationismainlylimitedtotubulinincorporatedintoaxonemes(ciliaandflagella)whereasglutamylationisprevalentinneuronalcells,centrioles,axonemes,andthemitoticspindle.Bothmodificationscancoexistonthesameproteinonadjacentresidues,andloweringglycylationlevelsincreasespolyglutamylation,andreciprocally.TheprecisefunctionofsuchmodificationsisstillunclearbuttheyregulatetheassemblyanddynamicsofaxonemalmicrotubulesProbable.

      PhosphorylatedonSer-172byCDK1duringthecellcycle,frommetaphasetotelophase,butnotininterphase.Thisphosphorylationinhibitstubulinincorporationintomicrotubules.

      INVOLVEMENTINDISEASE:DefectsinTUBB3arethecauseofcongenitalfibrosisofextraocularmusclestype3A(CFEOM3A)[MIM:600638].Acongenitalocularmotilitydisordermarkedbyrestrictiveophthalmoplegiaaffectingextraocularmusclesinnervatedbytheoculomotorand/ortrochlearnerves.Itisclinicallycharacterizedbyanchoringoftheeyesindownwardgaze,ptosis,andbackwardtiltofthehead.Congenitalfibrosisofextraocularmusclestype3presentsasanon-progressive,autosomaldominantdisorderwithvariableexpression.Patientsmaybebilaterallyorunilaterallyaffected,andtheiroculo-motilitydefectsrangefromcompleteophthalmoplegia(withtheeyesfixedinahypo-andexotropicposition),tomildasymptomaticrestrictionsofocularmovement.Ptosis,refractiveerror,amblyopia,andcompensatoryheadpositionsareassociatedwiththemoresevereformsofthedisorder.Insomecasestheocularphenotypeisaccompaniedbyadditionalfeaturesincludingdevelopmentaldelay,corpuscallosumagenesis,basalgangliadysmorphism,facialweakness,polyneuropathy.

      SEQUENCESIMILARITIES:Belongstothetubulinfamily.
      MolecularWeightTheunconjugatedparentantibody(Cat.No.MAB1637)hasanobservedmolecularweightat~55kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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