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Millipore/ABS90 | Anti-Notch 1 Antibody, extracellular/ABS90/100 µL
  • Millipore/ABS90 | Anti-Notch 1 Antibody, extracellular/ABS90/100 µL

Millipore/ABS90 | Anti-Notch 1 Antibody, extracellular/ABS90/100 µL

價格: ￥3204.00 市場價: 5340.00
貨號: ABS90
品牌: Millipore
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    • Description
      CatalogueNumberABS90
      DescriptionAnti-Notch1Antibody,extracellular
      AlternateNames
      • Notchhomolog1,translocation-associated(Drosophila)
      • Notch(Drosophila)homolog1(translocation-associated)
      • Translocation-associatednotchproteinTAN-1
      • neurogeniclocusnotchhomologprotein1
      BackgroundInformationThenotchgenebelongstoafamilyofepidermalgrowthfactor(EGF)likehomeoticgenes,whichencodetransmembraneproteinswithavariablenumberofcysteine-richEGF-likerepeatsintheextracellularregion.Fournotchgeneshavebeendescribedinmammals,whichincludenotch-1.notch-2,notch-3,andnotch-4(Int-3),whichhavebeenimplicatedinthedifferentiationofthenervoussystemandotherstructures.TheEGF-likeproteinsDeltaandSerratehavebeenidentifiedasligandsofnotch-1.Maturenotchproteinsareheterodimericreceptorsderivedfromthecleavageofnotchpre-proteinsintoanextracellularsubunit(NEC)containingmultipleEGF-likerepeatsandatransmembranesubunitincludingintracellularregion(Ntm).
      ProductInformation
      FormatAffinityPurified
      Control
      • Humanlymphnodelysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-Notch1Antibody,extracellulardetectslevelofNotch1&hasbeenpublished&validatedforuseinWB,IH(P).
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistryAnalysis:1:400dilutionofthisantibodyhasbeenshowntodetectNotch1ingastrointestinalandcolorectalcarcinomatissue.
      BIOLOGicalInformation
      ImmunogenGST-taggedrecombinantproteincorrespondingtotheextracellulardomainofratNotch1.
      EpitopeExtracellulardomain
      HostRabbit
      SpecificityThisantibodyrecognizesNotch1.
      SpeciesReactivity
      • Human
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhumanandrat.Expectedtoreactwithmouse(97%sequencehomology),chimpanzee(92%sequencehomology)andcanine(91%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTransmembranereceptor;involvedincell-cellinteractionsimportantfordevelopmentandpatternformation[RGD].
      GeneSymbol
      • TAN1
      • notch1
      • hN1
      • Notch1
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity).ActsinstructivelytocontrolthecellfatedeterminationofCNSmultipotentProgenitorcells,resultinginastroglialinductionandneuron/oligodendrocytesuppression.

      SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1(Bysimilarity).

      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).

      Notch1intracellulardomain:Nucleus(Bysimilarity).Note:FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity).

      TISSUESPECIFICITY:Expressedinthebrain,kidneyandspleen.Expressedinpostnatalcentralnervoussystem(CNS)germinalzonesand,inearlypostnatallife,withinnumerouscellsthroughouttheCNS.Foundinbothsubventricularandventriculargerminalzones.

      DEVELOPMENTALSTAGE:Intheembryo,highestlevelsoccurbetweendays12and14anddecreaserapidlytomuchlowerlevelsintheadult.

      PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).

      Phosphorylated(Bysimilarity).

      O-glycosylatedontheEGF-likedomains.ContainsbothO-linkedfucoseandO-linkedglucose(Bysimilarity).

      SEQUENCESIMILARITIES:BelongstotheNOTCHfamily.

      Contains5ANKrepeats.

      Contains36EGF-likedomains.

      Contains3LNR(Lin/Notch)repeats.
      MolecularWeight~260kDaobserved.Notch1,extracellulariscalculatedat~183kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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