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Millipore/ABS82 | Anti-VEGF Antibody/ABS82/100 µg
  • Millipore/ABS82 | Anti-VEGF Antibody/ABS82/100 µg

Millipore/ABS82 | Anti-VEGF Antibody/ABS82/100 µg

價(jià)格: ￥3444.00 市場(chǎng)價(jià): 5740.00
貨號(hào): ABS82
品牌: Millipore
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    • Description
      CatalogueNumberABS82
      Replaces07-1376
      DescriptionAnti-VEGFAntibody
      AlternateNames
      • vascularendothelialgrowthfactorA
      • vascularendothelialgrowthfactor
      • VascularpermeABIlityfactor
      • vascularendothelialgrowthfactorisoformVEGF
      BackgroundInformationVEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.VEGFinducesangiogenesisaswellaspermeabilizationofbloodvessels,andplaysacentralroleintheregulationofvasculogenesis.VEGFexpressioncorrelatestothedegreeoftumorvascularizationandwithincreasedmetastaticrisk.Additionally,VEGFinducesendothelialcellproliferation,promotescellmigration,andinhibitsapoptosis.Consequently,inhibitionofVEGFsignalingabrogatesthedevelopmentofawidevarietyoftumors.
      ProductInformation
      FormatAffinityPurified
      Control
      • HuVeccelllysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationDetectVEGFusingthisAnti-VEGFAntibodyvalidatedforuseinWB,IH(P).
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistryAnalysis:1:400dilutionfromapreviouslotdetectedVEGFinnormalhumanplacentalvillitissue.
      BiologicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanVEGFattheN-terminus.
      EpitopeN-terminus
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesVEGFattheN-terminus.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Primate
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouse,andrat.Predictedtoreactwithprimatebasedon100%sequencehomology.
      Otherhomologies:Bovine(85%sequencehomology).Rat(70%sequencehomology).Mouse(65%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.[providedbyRefSeq].
      GeneSymbol
      • VPF
      • VEGF-A
      • MVCD
      • VEGF
      • VEGA
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.

      SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity).

      SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.

      ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing.
      MolecularWeight~55kDaobserved.UniProtKB/Swiss-ProtP15692(VEGFA_HUMAN)entrydescribes13isoformsproducedbyalternativepromoterusage,alternativesplicingandalternativeinitiation:Isoform1at27.042kDa,Isoform2at25.173kDa,Isoform3at24.422kDa,Isoform4at22.314kDa,Isoform5at20.218kDa,Isoform6at20.064kDa,Isoform7at22.259kDa,Isoform8at17.219kDa,Isoform9at15.981kDa,Isoform10at40.738kDa,Isoform11at35.643kDa,Isoform12at43.597kDa,Isoform13at45.467kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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