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Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg
  • Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

Millipore/ABS150 | Anti-phospho-PDGFRα (Tyr754) Antibody/ABS150/200 µg

價格: ￥3324.00 市場價: 5540.00
貨號: ABS150
品牌: Millipore
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    • Description
      CatalogueNumberABS150
      DescriptionAnti-phospho-PDGFRα(Tyr754)Antibody
      AlternateNames
      • Platelet-derivedgrowthfactorreceptoralpha
      • PDGF-R-alpha
      • PDGFR-alpha
      • Alphaplatelet-derivedgrowthfactorreceptor
      • Alpha-typeplatelet-derivedgrowthfactorreceptor
      • CD140antigen-likefamilymemberA
      • CD140aantigen
      • Platelet-derivedgrowthfactoralphareceptor
      • Platelet-derivedgrowthfactorreceptor2
      • Shortname=PDGFR-2
      • CD_antigen=CD140a
      BackgroundInformationPDGFRα(platelet-derivedgrowthfactor;Alpha-typeplatelet-derivedgrowthfactorreceptor;CD140antigen-likefamilymemberA)isaubiquitousreceptortyrosinekinase.Itisactivatedbythebindingofhomo-orheterodimersofPDGFA,PDGFBorPDGFC.Uponligandbinding,PDGFRαdimerizesastwoalphaortwobetasubunitsdependingonthecellularcontext,andisautophosphorylatedatmultipletyrosineresidues.Phosphorylatedtyrosineresiduesinteractwithdifferenttargetstomediatecellproliferation,migration,andsurvival.PhosphorylationatTyrosine754inducesheterodimerizationandallowsPDGFRαtointeractwithPTPN11.Inaddition,PDGRαregulatesapoptosisbymultiplesignalingpathwaysthatconvergeonproapoptoticproteinssuchasBAD.Forinstance,PDGFRαsignalingdeactivatesBADbyinductionofPI3K/Akt;PLC-gamma/PKC/Bcl-2;andRas/Raf/Erksignalingpathways.DefectivePDGFRαhasbeenimplicatedin?hypereosinophilicsyndromeandgastrointestinalstromaltumor.
      ProductInformation
      FormatAffinityPurified
      Control
      • UntreatedandPDGFtreatedNIH/3T3celllysates
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationDetectphospho-PDGFRα(Tyr754)usingthisAnti-phospho-PDGFRα(Tyr754)AntibodyvalidatedforuseinWesternBlotting.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanPDGFRαphosphorylatedat(Tyr754).
      EpitopePhosphorylated(Tyr754)
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesPDGFRαphosphorylatedat(Tyr754).
      SpeciesReactivity
      • Mouse
      • Human
      • Rat
      • Bovine
      SpeciesReactivityNoteDemonstratedtoreactwithMouse.PredictedtoreactwithHuman,Rat,andBovinebasedon100%sequencehomology.Otherhomologies:XenopusandChicken(91%sequencehomology).
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesacellsurfacetyrosinekinasereceptorformembersoftheplatelet-derivedgrowthfactorfamily.Thesegrowthfactorsaremitogensforcellsofmesenchymalorigin.Theidentityofthegrowthfactorboundtoareceptormonomerdetermineswhetherthefunctionalreceptorisahomodimeroraheterodimer,composedofbothplatelet-derivedgrowthfactorreceptoralphaandbetapolypeptides.Studiesinknockoutmice,wherehomozygosityislethal,indicatethatthealphaformoftheplatelet-derivedgrowthfactorreceptorisparticularlyimportantforkidneydevelopmentsincemiceheterozygousforthereceptorexhibitdefectivekidneyphenotypes.[providedbyRefSeq,Jul2008].
      GeneSymbol
      • PDGFRA
      • PDGFR2
      • RHEPDGFRA
      Modifications
      • Phosphorylation
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Tyrosine-proteinkinasethatactsasacell-surfacereceptorforPDGFA,PDGFBandPDGFCandplaysanessentialroleintheregulationofembryonicdevelopment,cellproliferation,survivalandchemotaxis.Dependingonthecontext,promotesorinhibitscellproliferationandcellmigration.Playsanimportantroleinthedifferentiationofbonemarrow-derivedmesenchymalstemcells.Requiredfornormalskeletondevelopmentandcephalicclosureduringembryonicdevelopment.Requiredfornormaldevelopmentofthemucosaliningthegastrointestinaltract,andforrecruitmentofmesenchymalcellsandnormaldevelopmentofintestinalvilli.Playsaroleincellmigrationandchemotaxisinwoundhealing.Playsaroleinplateletactivation,secretionofagoNISTsfromplateletgranules,andinthrombin-inducedplateletaggregation.Bindingofitscognateligands-homodimericPDGFA,homodimericPDGFB,heterodimersformedbyPDGFAandPDGFBorhomodimericPDGFC-leadstotheactivationofseveralsignalingcascades;theresponsedependsonthenatureoftheboundligandandismodulatedbytheformationofheterodimersbetweenPDGFRAandPDGFRB.PhosphorylatesPIK3R1,PLCG1,andPTPN11.ActivationofPLCG1leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol-1,4,5-trisphosphate,mobilizationofcytosolicCa2+andtheactivationofproteinkinaseC.PhosphorylatesPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,andtherebymediatesactivationoftheAKT1signalingpathway.MediatesactivationofHRASandoftheMAPkinasesMAPK1/ERK2and/orMAPK3/ERK1.PromotesactivationofSTATfamilymembersSTAT1,STAT3andSTAT5Aand/orSTAT5B.Receptorsignalingisdown-regulatedbyproteinphosphatasesthatdephosphorylatethereceptoranditsdown-streameffectors,andbyrapidinternalizationoftheactivatedreceptor.

      CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

      ENZYMEREGULATION:Presentinaninactiveconformationintheabsenceofboundligand.BindingofPDGFAand/orPDGFBleadstodimerizationandactivationbyautophosphorylationontyrosineresidues.Inhibitedbyimatinib,nilotinibandsorafenib.

      SUBUNITSTRUCTURE:InteractswithhomodimericPDGFA,PDGFBandPDGFC,andwithheterodimersformedbyPDGFAandPDGFB.Monomerintheabsenceofboundligand.InteractionwithdimericPDGFA,PDGFBand/orPDGFCleadstoreceptordimerization,wherebothPDGFRAhomodimersandheterodimerswithPDGFRBareobserved.Interacts(tyrosinephosphorylated)withSHB(viaSH2domain)(Bysimilarity).Interacts(tyrosinephosphorylated)withSHF(viaSH2domain).Interacts(tyrosinephosphorylated)withSRC(viaSH2domain).Interacts(tyrosinephosphorylated)withPIK3R1.Interacts(tyrosinephosphorylated)withPLCG1(viaSH2domain).Interacts(tyrosinephosphorylated)withCRK,GRB2andGRB7.SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein.Note:Theactivatedreceptorisrapidlyinternalizedanddegraded.

      TISSUESPECIFICITY:Detectedinplatelets(atproteinlevel).Widelyexpressed.Detectedinbrain,fibroblasts,smoothmuscle,heart,andembryo.Expressedinprimaryandmetastaticcolontumorsandinnormalcolontissue.

      PTM:N-glycosylated.

      Ubiquitinated,leADIngtoitsdegradationProbable.

      Autophosphorylatedontyrosineresiduesuponligandbinding.Autophosphorylationoccursintrans,i.e.onesubunitofthedimericreceptorphosphorylatestyrosineresiduesontheothersubunit.PhosphorylationatTyr-731andTyr-742isimportantforinteractionwithPIK3R1.PhosphorylationatTyr-720andTyr-754isimportantforinteractionwithPTPN11.PhosphorylationatTyr-762isimportantforinteractionwithCRK.PhosphorylationatTyr-572andTyr-574isimportantforinteractionwithSRCandSRCfamilymembers.PhosphorylationatTyr-988andTyr-1018isimportantforinteractionwithPLCG1.

      INVOLVEMENTINDISEASE:Note=AchromosomalaberrationinvolvingPDGFRAisfoundinsomecasesofhypereosinophilicsyndrome.Interstitialchromosomaldeletiondel4(q12q12)causesthefusionofFIP1L1andPDGFRA(FIP1L1-PDGFRA).Mutationsthatcauseoverexpressionand/orconstitutiveactivationofPDGFRAmaybeacauseofhypereosinophilicsyndrome.

      DefectsinPDGFRAareacauseofgastrointestinalstromaltumor(GIST)[MIM:606764].Note=MutationsthatcauseconstitutiveactivationofPDGFRAmaybeacauseofgastrointestinalstromaltumor(GIST).

      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.CSF-1/PDGFreceptorsubfamily.

      Contains5Ig-likeC2-type(immunoglobulin-like)domains.

      Contains1proteinkinasedomain.

      SEQUENCECAUTION:ThesequenceAAP69563.1differsfromthatshown.Reason:Erroneousinitiation.TranslationN-terminallyshortened.
      MolecularWeight~180kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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