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Millipore/AB980 | Anti-Myelin Basic Protein Antibody/AB980/500 µL
  • Millipore/AB980 | Anti-Myelin Basic Protein Antibody/AB980/500 µL

Millipore/AB980 | Anti-Myelin Basic Protein Antibody/AB980/500 µL

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貨號: AB980
品牌: Millipore
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    • Description
      CatalogueNumberAB980
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MyelinBasicProteinAntibody
      AlternateNames
      • MyelinA1protein
      • Myelinmembraneencephalitogenicprotein
      BackgroundInformationTheclassicgroupofMyelinbasicprotein(MBP)isoforms(isoforms4to14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.TheyhavearoleinbothitsformationandstABIlization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.ThenonclassicgroupofMBPisoforms(isoforms1to3/GolliMBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinTcellsandneuralcells.Differentialsplicingeventscombinedtooptionalposttranslationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.
      ProductInformation
      FormatPurified
      Control
      • Braintissue,brainlysate
      PresentationLiquidin0.05mol/LTris-HCl,pH7.6with15mmol/Lsodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8oCfromdateofreceipt.
      Applications
      ApplicationThisAnti-MyelinBasicProteinAntibodyisvalidatedforuseinIH,IH(P),WBforthedetectionofMyelinBasicProtein.
      KeyApplications
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:
      1:200dilutionofapreviouslotwasusedbyPAPorABConformalinfixed,paraffin-embeddedhumanspinalcord.Pretreatmentoftissuewithproteolyticenzymeisnotrequired.

      WesternBlot:
      Adilutionof1:3000wasusedinTTBS,O/N4°Conapreviouslot.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenHumanmyelinbasicproteinfrombrain
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificitySuitableforlabelingofoligodendrocytesandmyelinofwhitematterinbrainandspinalcord(graymatterstainslessabundantly).Alsostainsperipheralnerves.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.
      GeneSymbol
      • MBP
      • MGC99675
      • Golli-mbp
      PurificationMethodAmmoniumSulfatePrecipitation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.Theyhavearoleinbothitsformationandstabilization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
      SIZE:304aminoacids;33117Da
      SUBUNIT:Homodimer;isoform3existsasahomodimer.
      SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
      TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.
      DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
      PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
      DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
      SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
      MolecularWeight21,18,17&14kDa.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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