BackgroundInformation | Tubulins,majorcomponentsofthecellularCytoskeleton,formmicrotubulesthatarecriticalforcellularstructure,migration,celldivision,andintracellulartrafficking.Thereareatleastthreetypesoftubulins:alpha,beta,andgamma.Eachhasamolecularweightofapproximately55kDa.Microtubulesarelargestructures(300angstromdiameter)composedofalternatingalphaandbetasubunits.Compoundsthatblockmicrotubleformation,suchasTaxolandthevincaalkaloids,inhibitcelldivisionandareeffectiveanti-canceragents.ClassIIIβ-tubulin?isamicrotubuleelementexpressedexclusivelyinneurons,andisapopularMarkerspecificforneuronsintissue. |