Immunogen | RecombinantproteinfromthecytoplasmictailofmouseCrim1. |
Host | Rabbit |
Specificity | Crim1
SUBCELLULARLOCALIZATION:IntracellularandMembraneassociated. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Motorneuronsareamongtheearliestneuronstoappearafterthecommencementofcellpatterningandthebeginningofcelldifferentiation.Differentiationoccursinaventral-to-dorsalgrADIentandismediated,atleastinpart,bytheconcentrationofventrallyexpressedsonichedgehogprotein(SHH;MIM600725).Dorsallyexpressedfactors,suchasmembersofthebonemorphogenicprotein(e.g.,BMP4;MIM112262)andtransforminggrowthfactor-beta(e.g.,TGFB1;MIM190180)families,canrepresstheinductionoftheseneurons.CRIM1mayinteractwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival(Kolleetal.,2000[PubMed10642437]).[suppliedbyOMIM] |
GeneSymbol | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q9NZV1#MayplayaroleinCNSdevelopmentbyinteractingwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival.Mayplayaroleincapillaryformationandmaintenanceduringangiogenesis.ModulatesBMPactivitybyaffectingitsprocessinganddeliverytothecellsurface. SIZE:1036aminoacids;113738Da SUBUNIT:InteractswithBMP4andBMP7. SUBCELLULARLOCATION:Processedcysteine-richmotorneuron1protein:Secreted.&Cellmembrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Expressedinpancreas,kidney,skeletalmuscle,lung,placenta,brain,heart,spleen,liverandsmallintestine.Expressedinbloodvessels(atproteinlevel). PTM:N-glycosylated. SIMILARITY:SwissProt:Q9NZV1##Contains4antistasin-likedomains.&Contains1IGFBPN-terminaldomain.&Contains6VWFCdomains. |