Immunogen | PurifiedbovinebrainMAP2 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Chicken |
Specificity | MicrotubuleAssociatedProtein2(MAP2).Itisexpectedthattheantibodywillreactwithallmammals. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.Theproductsofsimilargenesinratandmouseareneuron-specificcytoskeletalproteinsthatareenrichedindentrites,implicatingaroleindeterminingandstABIlizingdentriticshapeduringneurondevelopment.Anumberofalternativelysplicedvariantsencodingdistinctisformshavebeendescribed. |
GeneSymbol | - MAP2
- MAP2B
- MAP-2
- MAP2C
- DKFZp686I2148
- MAP2A
|
PurificationMethod | AmmoniumSulfatePrecipitation |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules. SIZE:1827aminoacids;199539Da PTM:MAP2A/cisphosphorylated.PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P11137##Contains3Tau/MAPrepeats. |
MolecularWeight | Recognizesadoubletof~280kDaandadoubletof~70kDa. |