Immunogen | Peptidecorrespondingtotheaminoacids11-26ofhumana,b,andg(82%)-synucleinprotein.Thepeptidewaschosensothattheantibodywouldrecognizeallthreeformsofsynuclein. |
Host | Rabbit |
Specificity | Pansynuclein.Initialtestingbyimmunohistochemistryindicatesthattheantibodystainingpatternoverlapsalpha,beta,andgamma-synucleinmaps. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneishighlyhomologoustoalpha-synuclein.TheseproteinsareabundantlyexpressedinthebrainandputativelyinhibitphospholipaseD2selectively.Theencodedprotein,whichmayplayaroleinneuronalplasticity,isabundantinneurofibrillarylesionsofpatientswithAlzheimerdisease.Thisproteinhasbeenshowntobehighlyexpressedinthesubstantianigraofthebrain,aregionofneuronaldegenerationinpatientswithParkinsondisease;however,nodirectrelationtoParkinsondiseasehasbeenestablished.Twotranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. |
GeneSymbol | - SNCA
- PD1
- alpha-synuclein
- NACP
- PARK4
- MGC110988
- PARK1
- Alpha-synuclein
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q16143#Non-amyloidcomponentofsenileplaquesfoundinAlzheimerdisease.CouldactasaregulatorofSNCAaggregationprocess.Protectsneuronsfromstaurosporineand6hydroxydopamine(6OHDA)-stimulatedcaspaseactivationinap53-dependentmanner.ContributestorestoretheSNCAanti-apoptoticfunctionabolishedby6OHDA.NotfoundintheLewybodiesassociatedwithParkinsondisease. SIZE:134aminoacids;14288Da SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Expressedpredominantlyinbrain;concentratedinpresynapticnerveterminals. PTM:Phosphorylated.PhosphorylationbyG-proteincoupledreceptorkinases(GRK)ismoreefficientthanphosphorylationbyCK1,CK2andCaM-kinaseII. DISEASE:SwissProt:Q16143#Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCBisfoundinspheroidsbutnotininclusions. SIMILARITY:SwissProt:Q16143##Belongstothesynucleinfamily. |