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Millipore/AB5388 | Anti-Synphilin-1 Antibody, a.a. 829-847/AB5388/50 µL
  • Millipore/AB5388 | Anti-Synphilin-1 Antibody, a.a. 829-847/AB5388/50 µL

Millipore/AB5388 | Anti-Synphilin-1 Antibody, a.a. 829-847/AB5388/50 µL

價(jià)格: ￥3948.00 市場價(jià): 6580.00
貨號(hào): AB5388
品牌: Millipore
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    • Description
      CatalogueNumberAB5388
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Synphilin-1Antibody,a.a.829-847
      AlternateNames
      • Alpha-SynucleinInteractingProtein
      ProductInformation
      FormatSerum
      PresentationRabbitserum.Lyophilized.Containsnopreservative.Reconstitutewith50μLofsteriledistilledwater.Centrifugeifnecessarytoremoveanyresidue.
      StorageandShippingInformation
      StorageConditionsMaintainlyophilizedmaterialat-20°Cto-70°Cforupto6months.Afterreconstitutionmaintainfrozenat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-Synphilin-1Antibody,a.a.829-847detectslevelofSynphilin-1&hasbeenpublished&validatedforuseinIH.
      KeyApplications
      • Immunohistochemistry
      ApplicationNotesImmunohistochemistry:1:1,000-1:2,000.

      Note:TheantibodyhasalsobeenusedsuccessfullyforWesternblotbutresultsmayvaryfromlabtolab.TheusefulnessoftheantibodyforWesternblotmustbedeterminedbyeachindividuallaboratory.

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenAsyntheticpeptidefromhumansynphilin-1(aminoacids829-847).
      Epitopea.a.829-847
      HostRabbit
      SpecificitySynphilin-1.Immunohistochemicalanalysisofhumanbrainindicatesahighlevelofspecificity.Peptidesequenceusedshows88%sequencehomologywithmousesynphilin-1butmousehasnotbeentestedforreactivity.
      SpeciesReactivity
      • Human
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaproteincontainingseveralprotein-proteininteractiondomains,includingankyrin-likerepeats,acoiled-coildomain,andanATP/GTP-bindingmotif.Theencodedproteininteractswithalpha-synucleininneuronaltissueandmayplayaroleintheformationofcytoplasmicinclusionsandneurodegeneration.AmutationinthisgenehasbeenassociatedwithParkinson"sdisease.Alternativelysplicedtranscriptvariantsencodingdifferentisoformsofthisgenehavebeendescribed,buttheirfull-lengthnaturehasyettobedetermined.
      GeneSymbol
      • SNCAIP
      • MGC39814
      • synphilin-1
      • SYPH1
      • Synphilin-1
      UniProtNumber
      UniProtSummarySIZE:919aminoacids;100381Da
      SUBUNIT:AssociateswithSNCA,RNF19AANDPARK2.
      TISSUESPECIFICITY:Widelyexpressed,withhighestlevelsinbrain,heartandplacenta.
      PTM:Ubiquitinated;mediatedbySIAH1orRNF19AandleADIngtoitssubsequentproteasomaldegradation.
      DISEASE:SwissProt:Q9Y6H5#DefectsinSNCAIPareacauseofParkinsondisease(PD)[MIM:168600].PDisacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.
      SIMILARITY:SwissProt:Q9Y6H5##Contains6ANKrepeats.
      MISCELLANEOUS:ConstructsencodingportionsofSNCAandSNCAIPco-transfectedinmammaliancellspromotecytosolicinclusionsresemblingtheLewybodiesofParkinsondisease.CoexpressionofSNCA,SNCAIP,andPARK2resultintheformationofLewybody-likeubiquitin-positivecytosolicinclusions.FamilialmutationsinPARK2disrupttheubiquitinationofSNCAIPandtheformationoftheubiquitin-positiveinclusions.TheseresultsprovideamolecularbasisfortheubiquitinationofLewybody-associatedproteinsandlinkPARK2andSNCAinacommonpathogenicmechanismthroughtheirinteractionwithSNCAIP.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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