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Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg
  • Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg

Millipore/AB5320 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody/AB5320/100 µg

價(jià)格: ￥4440.00 市場價(jià): 7400.00
貨號: AB5320
品牌: Millipore
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    • Description
      CatalogueNumberAB5320
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NG2ChondroitinSulfateProteoglycanAntibody
      AlternateNames
      • ChondroitinsulfateproteoglycanNG2
      • Melanomachondroitinsulfateproteoglycan3
      • Melanoma-associatedchondroitinsulfateproteoglycan
      • chondroitinsulfateproteoglycan4
      • chondroitinsulfateproteoglycan4(melanoma-associated)
      BackgroundInformationNG2(alsoknownasChondroitinsulfateproteoglycan4,ChondroitinsulfateproteoglycanNG2,Melanomachondroitinsulfateproteoglycan,andMelanoma-associatedchondroitinsulfateproteoglycanis)ahighmolecularweight,integralmembranechondroitinsulfateproteoglycan.Itisfoundonthesurfacesofanunusualclassofglialcellswithinthedevelopingandmaturecentralnervoussystemthathavethepropertiesofoligodendrocyteprecursorcells(i.e.,O-2AProgenitorcells).NG2isalsofoundonthesurfacesofchondroblasts,proliferatingcapillaryendothelialcells,somehumanmelanomacelllines,andonleukemicblastsinchildhoodacutelymphoblasticleukemia.TheNG2proteoglycanislikelytoplayaroleinregulationofcellmotility,axonoutgrowthandthecellularresponsestoplatelet-derivedgrowthfactor.
      ProductInformation
      FormatAffinityPurified
      Control
      • Humanmelanoma,gliomaandproliferatingbrainendothelialcells,ratB49glialcellextractsorembryonicmousebraintissue.
      PresentationPurifiedrabbitpolyclonalinPBSbuffercontaining0.02%azide.
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat-20oCinundilutedaliquotsfromdateofreceipt.

      HandlingRecommendations:
      Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationDetectNG2ChondroitinSulfateProteoglycanusingthisAnti-NG2ChondroitinSulfateProteoglycanAntibodyvalidatedforuseinELISA,IC,IH,IPandWB.
      KeyApplications
      • ELISA
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunocytochemistry:
      A1:150-1:600dilutionofapreviouslotwasusedinIC.

      Immunohistochemistry:
      1:200dilutionofapreviouslotwasusedonfrozensectionsofembryonicmousebrainusinganAlexaFluorconjugatedsecondaryantibody.Careshouldbetakentoavoidoverfixingtissuesections.Ashort(5-10minute)fixin2-4%PFAisrecommended.

      Immunoprecipitation:
      2μg/mLconcentrationofapreviouslotwasusedinIP.

      ELISA:
      A1:1,500-1:3,000dilutionofapreviouslotwasusedinELISA.

      Optimalworkingdilutionsandprotocolsmustbedeterminedbyenduser
      BIOLOGicalInformation
      ImmunogenImmunoaffinitypurifiedNG2ChondroitinSulfateProteoglycanfromrat.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityNG2ChondroitinSulfateProteoglycan.AB5320identifiesboththeintactproteoglycanandthecoreproteinbyWesternblotandELISA.Whenoligodendrocyteprecursorcells(i.e.O-2Aprogenitorcells)arestainedalive,thestainappearsasclustersonthecellsurface.Thisantibodydoesnotstaindifferentiatedoligodendrocyteswell.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Monkey
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
      GeneSymbol
      • CSPG4
      • MSK16
      • MCSP
      • NG2
      • MCSPG
      • MEL-CSPG
      • HMW-MAA
      PurificationMethodAntibodypurifiedbyproteinA,thenplacedoverafibronectinaffinitycolumn.
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.
      SIZE:2322aminoacids;250497Da
      SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.
      SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).
      TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.
      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).
      SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.
      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells
      MolecularWeight270-300kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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