當(dāng)前位置 ： Millipore >>> Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg
Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg
  • Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

Millipore/AB4251 | Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular/AB4251/50 µg

價格: ￥4308.00 市場價: 7180.00
貨號: AB4251
品牌: Millipore
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產(chǎn)品：無質(zhì)量問題不接受退換貨，下單前請仔細(xì)核對信息。
下單后請及時聯(lián)系客服核對商品價格，訂單生效后再付款。
資深產(chǎn)品顧問
咨詢顧問

全國免費服務(wù)熱線

4000-520-616

  • 自營商城 一站式服務(wù)
  • 廠家直采 剔除溢價
  • 品質(zhì)甄選 正品保證
  • 嚴(yán)控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
    • Description
      CatalogueNumberAB4251
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-CXCChemokineReceptor4Antibody,NT,extracellular
      AlternateNames
      • CXCR4
      BackgroundInformationCXCR4isachemokinereceptorinvolvedinorganvascularization,neuronalcellmigration,andpatterningofthecentralnervoussystemduringdevelopment.Itbindsstromalcell-derivedfactor1(SDF1)andmediatesmigrationofrestingleukocytesandisuniqueinhominghematopoieticProgenitorstobonemarrow.ThesepropertiessuggestthatCXCR4isinvolvedintumorcellmigrationandlocaltumorinvasion.ItisalsoanHIV-1fusionco-factorthatallowsHIV-1invasionindiversehumancelltypes.CXCR4hastwoisoformsthatareproducedbyalternativesplicingandhasbeenreportedtobeexpressedincellsoftheimmuneandcentralnervoussystems.Itishighlyexpressedinbrainandheart,andinwhitebloodcells,vascularendothelialcells,andumbilicalcordendothelialcells.Inbraintumors,CXCR4isexpressedinregionsofangiogenesisanddegenerative,necrotic,andmicrocysticchanges(Rempeletal.,2000).ESTshavebeenisolatedfromawidevarietyoftissuelibraries,particularlyuterus,kidney,lung,tonsil,andbrain.
      ProductInformation
      FormatAffinityPurified
      PresentationPeptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide
      StorageandShippingInformation
      StorageConditionsMaintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationThisAnti-CXCChemokineReceptor4Antibody,N-terminal,extracellularisvalidatedforuseinIH(P)forthedetectionofCXCChemokineReceptor4.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistry(formalin-fixedparaffin-embeddedtissues)

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoasequencewithintheN-terminalextracellulardomainofhumanCXCR4.Theimmunogenhas93%homologywithmouseandrat.
      EpitopeN-terminal,extracellular
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizeshumanCXCR4.ThespecificityofthisantibodyhasbeenconfirmedbyIHCstainingofcardiacmyocytesinhumanheart.
      SpeciesReactivity
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized.
      GeneSymbol
      • CXCR4
      • WHIM
      • NPY3R
      • NPYY3R
      • FB22
      • LAP3
      • Fusin
      • CXCR-4
      • LCR1
      • NPYR
      • HM89
      • fusin
      • HSY3RR
      • CXC-R4
      • NPYY3
      • NPYRL
      • CD184
      • D2S201E
      • LESTR
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus.
      SIZE:352aminoacids;39746Da
      SUBUNIT:InteractswithHIV-1surfaceproteingp120andTat.
      SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.
      TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested.
      DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity.
      PTM:Sulfated.
      DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis.
      SIMILARITY:BelongstotheG-proteincoupledreceptor1family.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    螞蟻淘生物188，秉承螞蟻淘一貫的嚴(yán)謹(jǐn)態(tài)度，由螞蟻淘公司專業(yè)人員負(fù)責(zé)品控、采購、物流、銷售、售后，保障正品優(yōu)質(zhì)。以“快速好省，為科研提供好產(chǎn)品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴(yán)格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產(chǎn)品帶給科研！? 力求給你最優(yōu)質(zhì)的商品。
  • Q：生物188產(chǎn)品正品保障嗎？
    A：生物188質(zhì)量把控人員具有十年的從業(yè)經(jīng)驗，在業(yè)界享有良好的口碑；自營商城，直接從廠家采購， 自己的團(tuán)隊負(fù)責(zé)國際物流和清關(guān)，中間沒有第三方，所有流程嚴(yán)格把控，100%保證正品，假一罰十。

    Q：下單后可以修改訂單嗎？
    A：下單后的商品付款之前可以修改；訂單付款成功，需要聯(lián)系我們客服進(jìn)行修改；客服電話：4000-520-616

    Q：可以開發(fā)票嗎？
    A：本網(wǎng)站所售商品都是正規(guī)清關(guān)，均開具16%正規(guī)發(fā)票，發(fā)票金額含配送費金額，另有說明的除外。

    Q：商品幾天可以發(fā)貨？
    A：生物188商品，全部現(xiàn)貨銷售，付款后即可發(fā)貨,一般一周內(nèi)送達(dá)！

    Q：如何聯(lián)系商家？
    A：有任何問題夠可以電話咨詢我們，全國24小時免費服務(wù)熱線：4000-520-616 或聯(lián)系我們的在線客服QQ：1570468124

    Q：收到的商品少了/發(fā)錯了怎么辦？
    A：同個訂單購買多個商品可能會分為一個以上包裹發(fā)出，可能不會同時送達(dá)，建議查看訂單詳情是否是 部分發(fā)貨狀態(tài)；如未收到，可聯(lián)系在線客服或者致電4000-520-616。

    Q：退換貨/維修需要多長時間？
    A：一般情況下，退貨處理周期為客戶收到產(chǎn)品一個月內(nèi)（以快遞公司顯示簽收時間為準(zhǔn)），包裝規(guī)格、 數(shù)量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內(nèi)申請退換貨；特殊商品以合同條款為準(zhǔn)。

何為188

極簡而嚴(yán)謹(jǐn)，我們僅銷售188款生物醫(yī)學(xué)科研用品，款款都是爆款；因為少所以聚焦，聚焦甄選每一款產(chǎn)品，聚焦服務(wù)每一位客戶!

關(guān)注我們 :

點擊QQ聯(lián)系我們
生物188微信

關(guān)注188微信公眾號

獲取最新優(yōu)惠活動通知

  • 品質(zhì)甄選，正品保證

  • 自營電商，廠家直采

  • 極簡主義，188精品