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Millipore/AB4250 | Anti-CXC Chemokine Receptor 3 Antibody, CT domain/AB4250/50 µg
  • Millipore/AB4250 | Anti-CXC Chemokine Receptor 3 Antibody, CT domain/AB4250/50 µg

Millipore/AB4250 | Anti-CXC Chemokine Receptor 3 Antibody, CT domain/AB4250/50 µg

價(jià)格: ￥4308.00 市場價(jià): 7180.00
貨號(hào): AB4250
品牌: Millipore
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    • Description
      CatalogueNumberAB4250
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-CXCChemokineReceptor3Antibody,CTdomain
      AlternateNames
      • CXCR3
      BackgroundInformationCXCR3,achemokinereceptor,ishighlysimilartotheinterleukin8BreceptorandhasbeenshowntomediaterecruitmentofTcellstositesofinflammationandretentionofT-cellsintheinflamedCNS.CXCR3hasbeensuggestedtobetheprincipalinflammatorychemokinereceptorinvolvedinintrathecalaccumulationofT-cellsinmultiplesclerosisanddiabetes.ItisexpressedonmalignantBcellsinchroniclymphoproliferativedisorders(Jonesetal.,2000).Analternativelysplicedisoform,CXCR3B,hasrecentlybeenidentified(Lasagnietal.,2003).CXCR3expressionhasbeendocumentedinthebrain,lymphoidandotherperipheraltissues,andindiseasesincludingatherosclerosis,Alzheimer"s,multiplesclerosis,rheumatoidarthritis,lymphomas,asthma,neoplasms,leukemia,andinflammatoryconditionsofvariousorgans.
      ProductInformation
      FormatAffinityPurified
      PresentationPeptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazide
      StorageandShippingInformation
      StorageConditionsMaintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-CXCChemokineReceptor3Antibody,C-terminaldomaindetectslevelofCXCChemokineReceptor3&hasbeenpublished&validatedforuseinIH(P).
      KeyApplications
      • Immunohistochemistry(Paraffin)
      ApplicationNotesImmunohistochemistry(formalin-fixedparaffin-embeddedtissues)

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoasequencewithintheC-terminaldomainofhumanCXCR3.Theimmunogenhas82%homologywithratandmouse.
      EpitopeC-terminaldomain
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizeshumanCXCR3.ThespecificityofthisantibodyhasbeenevaluatedbyIHCstainingofhumantonsil.
      SpeciesReactivity
      • Human
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryCD183isaGprotein-coupledreceptorwithselectivityforthreechemokines,termedIP10(interferon-g-inducIBLe10kDaprotein),Mig(monokineinducedbyinterferon-g)andI-TAC(interferon-inducibleTcella-chemoattractant).IP10,MigandI-TACbelongtothestructuralsubfamilyofCXCchemokines,inwhichasingleaminoacidresidueseparatesthefirsttwooffourhighlyconservedCysresidues.Historically,CD183isthethirdCXCchemokinereceptordiscoveredand,therefore,commonlydesignatedasCXCR3.BindingofchemokinestoCD183inducescellularresponsesthatareinvolvedinleukocytetraffic,mostnotablyintegrinactivation,cytoskeletalchangesandchemotacticmigration.InhibitionbyBordetellapertussistoxinsuggeststhatheterotrimericGproteinoftheGi-subclasscoupletoCD183.Signaltransductionhasnotbeenfurtheranalyzedbutmayincludethesameenzymesthatwereidentifiedinthesignalingcascadeinducedbyotherchemokinereceptors.Asaconsequenceofchemokine-inducedcellulardesensitization(phosphorylation-dependentreceptorinternalization),cellularresponsesaretypicallyrapidandshortinduration.Cellularresponsivenessisrestoredafterdephosphorylationofintracellularreceptorsandsubsequentrecyclingtothecellsurface.AhallmarkofCD183isitsprominentexpressionininvitroculturedeffector/memoryTcells,andinTcellspresentinmanytypesofinflamedtissues.Inaddition,IP10,MigandI-TACarecommonlyproducedbylocalcellsininflammatorylesion,suggestingthatCD183anditschemokinesparticipateintherecruitmentofinflammatorycells.Therefore,CD183isatargetforthedevelopmentofsmallmolecularweightantagoNISTs,whichmaybeusedinthetreatmentofdiverseinflammatorydiseases.
      GeneSymbol
      • CXCR3
      • CD182
      • CXC-R3
      • IP10-R
      • IP10
      • Mig-R
      • CD183
      • CKR-L2
      • CMKAR3
      • GPR9
      • CXCR-3
      • MigR
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P49682#ReceptorforCXCL9,CXCL10andCXCL11andmediatestheproliferationofhumanmesangialcells(HMC).Isoform2isareceptorforCXCL4andalsomediatestheinhibitoryactivitiesofCXCL9,CXCL10andCXCL11onthegrowthofhumanmicrovascularendothelialcells(HMVEC).Isoform2mayplayaroleinangiogenesis.Isoform3mediatesactivityofCXCL11.
      SIZE:368aminoacids;40660Da
      SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.
      TISSUESPECIFICITY:Isoform1andisoform2aremainlyexpressedinheart,kidney,liverandskeletalmuscle.Isoform1isalsoexpressedinplacenta.
      SIMILARITY:SwissProt:P49682##BelongstotheG-proteincoupledreceptor1family.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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