Immunogen | KLH-conjugated,syntheticphospho-peptidecorrespondingtoresiduessurroundingTyr14ofhumancaveolin-1 |
Epitope | phospho-specific(Tyr14) |
Host | Rabbit |
Specificity | Recognizescaveolin-1onlywhenphosphorylatedattyrosine14.Thisantibodydoesnotcross-reactwithcaveolin-2,-3orcaveolin-1beta,ortheshortisoformofcaveolin-1. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thescaffoldingproteinencodedbythisgeneisthemaincomponentofthecaveolaeplasmamembranesfoundinmostcelltypes.TheproteinlinksintegrinsubunitstothetyrosinekinaseFYN,aninitiatingstepincouplingintegrinstotheRas-ERKpathwayandpromotingcellcycleprogression.ThegeneisatumorsuppressorgenecandidateandanegativeregulatoroftheRas-p42/44MAPkinasecascade.CAV1andCAV2arelocatednexttoeachotheronchromosome7andexpresscolocalizingproteinsthatformastablehetero-oligomericcomplex.ByusingalternativeinitiationcodonsinthesamereADIngframe,twoisoforms(alphaandbeta)areencodedbyasingletranscriptfromthisgene. |
GeneSymbol | - CAV1
- MSTP085
- CAV
- VIP21
- Caveolin-1.
|
Modifications | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q03135#Mayactasascaffoldingproteinwithincaveolarmembranes.InteractsdirectlywithG-proteinalphasubunitsandcanfunctionallyregulatetheiractivity(Bysimilarity). SIZE:178aminoacids;20472Da SUBUNIT:Homooligomer.InteractswithGLIPR2,NOSTRIN,SNAP25andsyntaxin. SUBCELLULARLOCATION:Golgiapparatusmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellmembrane,caveola;Peripheralmembraneprotein;Cytoplasmicside.Note=Membraneproteinofcaveolae.Potentialhairpin-likestructureinthemembrane. TISSUESPECIFICITY:Inmuscleandlung,lesssoinliver,brainandkidney. PTM:TheinitiatormethionineforisoformBetaisremovedduringorjustaftertranslation.ThenewN-terminalaminoacidisthenN-acetylated. SIMILARITY:SwissProt:Q03135##Belongstothecaveolinfamily. |