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Millipore/AB1879 | Anti-Caspase 8 Antibody/AB1879/50 µg
  • Millipore/AB1879 | Anti-Caspase 8 Antibody/AB1879/50 µg

Millipore/AB1879 | Anti-Caspase 8 Antibody/AB1879/50 µg

價格: ￥4068.00 市場價: 6780.00
貨號: AB1879
品牌: Millipore
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    • Description
      CatalogueNumberAB1879
      Replaces04-573;04-574
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-Caspase8Antibody
      AlternateNames
      • MACH1
      • FLICE
      BackgroundInformationCaspase-8isa55kDacytosolicproteinthatissynthesizedasaninactiveproenzyme.Activationofcaspase-8involvesatwo-stepproteolysis:thecleavageofcaspase-8togeneratea43kDafragmentanda12kDawhichisfurtherprocessedto10kDa,andthenthep43isthencleavedtoyieldp26andthereleaseoftheactivesitecontainingp18.
      ProductInformation
      FormatAffinityPurified
      Control
      • Skin/Tumor,Embryo
      PresentationLiquidinPBS,pH7.2,containing30%glycerol,0.5%BSAand0.01%thiomerosal.AffinityPurifiedimmunoglobulin.
      StorageandShippingInformation
      StorageConditionsMaintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationThisAnti-Caspase8AntibodyisvalidatedforuseinWBforthedetectionofCaspase8.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternblot:0.5-4μg/mL

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      Immunogenrecombinant,fulllength,purifiedhumancaspase8
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityAB1879detects55and43kDaproteins,correspondingtotheproformandlargesubunitofcaspase-8.Theantibodyalsodetectshumanrecombinantcaspase-8proteinonSDS-PAGEimmunoblots.
      SpeciesReactivity
      • Bovine
      • Human
      • Mouse
      • Monkey
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymescomposedofaprodomain,alargeproteasesubunit,andasmallproteasesubunit.Activationofcaspasesrequiresproteolyticprocessingatconservedinternalasparticresiduestogenerateaheterodimericenzymeconsistingofthelargeandsmallsubunits.ThisproteinisinvolvedintheprogrammedcelldeathinducedbyFasandvariousapoptoticstimuli.TheN-terminalFADD-likedeatheffectordomainofthisproteinsuggeststhatitmayinteractwithFas-interactingproteinFADD.ThisproteinwasdetectedintheinsolublefractionoftheaffectedbrainregionfromHuntingtondiseasepatientsbutnotinthosefromnormalcontrols,whichimplicatedtheroleinneurodegenerativediseases.Manyalternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeendescribed,althoughnotallvariantshavehadtheirfull-lengthsequencesdetermined.
      GeneSymbol
      • CASP8
      • MGC78473
      • CASP-8
      • MACH
      • procaspase-8
      • MCH5
      • ALPS2B
      • FLICE
      • CAP4
      • EC3.4.22.61[Contains:Caspase-8subunitp18
      • Caspase-8subunitp10].
      PurificationMethodImmunoAffinityPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q14790#MostupstreamproteaseoftheactivationcascadeofcaspasesresponsIBLefortheTNFRSF6/FASmediatedandTNFRSF1Ainducedcelldeath.BindingtotheadaptermoleculeFADDrecruitsittoeitherreceptor.Theresultingaggregatecalleddeath-inducingsignalingcomplex(DISC)performsCASP8proteolyticactivation.TheactivedimericenzymeisthenliberatedfromtheDISCandfreetoactivatedownstreamapoptoticproteases.ProteolyticfragmentsoftheN-terminalpropeptide(termedCAP3,CAP5andCAP6)arelikelyretainedintheDISC.CleavesandactivatesCASP3,CASP4,CASP6,CASP7,CASP9andCASP10.MayparticipateintheGZMBapoptoticpathways.CleavesADPRT.Hydrolyzesthesmall-moleculesubstrate,Ac-Asp-Glu-Val-Asp--AMC.LikelytargetforthecowpoxvirusCRMAdeathinhibitoryprotein.Isoforms5,6,7and8lackthecatalyticsiteandmayinterferewiththepro-apoptoticactivityofthecomplex.
      SIZE:479aminoacids;55391Da
      SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya18kDa(p18)anda10kDa(p10)subunit.InteractswithFADD,CFLARandPEA15.Isoform9interactsattheendoplasmicreticulumwithacomplexcontainingBCAP31,BAP29,BCL2and/orBCL2L1.
      SUBCELLULARLOCATION:Cytoplasm.
      TISSUESPECIFICITY:Isoforms1,5and7areexpressedinawidevarietyoftissues.Highestexpressioninperipheralbloodleukocytes,spleen,thymus,andliver.Barelydetectableinbrain,testis,andskeletalmuscle.DOMAIN:SwissProt:Q14790Isoform9containsaN-terminalextensionthatisrequiredforinteractionwiththeBCAP31complex.
      PTM:Generationofthesubunitsrequiresassociationwiththedeath-inducingsignalingcomplex(DISC),whereasadditionalprocessingislikelyduetotheautocatalyticactivityoftheactivatedprotease.GZMBandCASP10canbeinvolvedintheseprocessingevents.&PhosphorylateduponDNAdamage,probablybyATMorATR.
      DISEASE:SwissProt:Q14790#DefectsinCASP8arethecauseofcaspase-8deficiency(CASP8D)[MIM:607271].CASP8Disadisorderresemblingautoimmunelymphoproliferativesyndrome(ALPS).Itischaracterizedbylymphadenopathy,splenomegaly,anddefectiveCD95-inducedapoptosisofperipheralbloodlymphocytes(PBLs).ItleadstodefectsinactivationofT-lymphocytes,B-lymphocytes,andnaturalkillercellsleADIngtoimmunodeficiencycharacterizedbyrecurrentsinopulmonaryandherpessimplexvirusinfectionsandpoorresponsestoimmunization.
      SIMILARITY:BelongstothepeptidaseC14family.&Contains2DED(deatheffector)domains.
      MolecularWeight55and43kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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