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Millipore/AB1783 | Anti-Glutamate Transporter Antibody, Glial/AB1783/50 µL
  • Millipore/AB1783 | Anti-Glutamate Transporter Antibody, Glial/AB1783/50 µL

Millipore/AB1783 | Anti-Glutamate Transporter Antibody, Glial/AB1783/50 µL

價(jià)格: ￥4440.00 市場(chǎng)價(jià): 7400.00
貨號(hào): AB1783
品牌: Millipore
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    • Description
      CatalogueNumberAB1783
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-GlutamateTransporterAntibody,Glial
      AlternateNames
      BackgroundInformationGlutamatetransporters(GluT)functiontoremoveL-glutamate(Glu),theprimaryexcitatoryneurotransmitterinthemammaliancentralnervoussystem(CNS),fromthesynapticcleft.ByclearingthesynapseinthismannerGlucanberecycledforlateruse,theproperdiffusiongrADIentcanbemaintainedandexcitotoxicitycanbeprevented.TherehavebeenreportsofmanydifferentmembersofaGluTmultigenefamily;GLT1,GLAST,EAAC1andEAAT2.mRNAhasbeenidentifiedinbrainforeachoftheseproteins.

      EAAT2transportsL-glutamateandalsoL-andD-aspartate.Itisessentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium.
      ProductInformation
      FormatSerum
      Control
      • Ratbraintissue
      PresentationGuineapigantiserumcontainingnopreservatives.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      Applications
      ApplicationDetectGlutamateTransporterusingthisAnti-GlutamateTransporterAntibody,GlialvalidatedforuseinIH(P),IF&WB.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      • Immunofluorescence
      • WesternBlotting
      ApplicationNotesEvaluatedbyWesternBlotonmousebrainmembranelysates.

      WesternBlot:1:500dilutionofthisantibodydetectedGLT-1on10ugofmousebrainmembranelysates.

      Immunohistochemistry:
      1:1,000-1:4,000dilutionfromapreviuoslotusedaDABdetectionsystemonadultratforebrainfixedwith4%paraformaldehyde.

      Immunohistochemistry:
      1:5,000-10,000dilutionfromapreviuoslotusedacyanineconjugatedsecondaryantibody.

      Enzymaticdetectionrequiressubstantiallyhigherprimaryantibodydilutions.Lightlyfixed4%PFAmaterialisrecommended.

      Notes:

      MaleSprague-Dawleyrats(b.wt.100-150g)wereanesthetizedwithsodiumpentobarbitalandperfusedviatheascendingaortawith50mLofCa2+-freeTyrode+ssolutionfollowedbyaformalin-picricacidfixative(4%paraformaldehydewith0.4%picricacidin0.16Mphosphatebuffer,pH6.9)for6minutes.Tissueswererapidlydissectedout,postfixedinthesamefixativefor90minutesandrinsedforatleast24hoursin0.1Mphosphatebuffer(pH7.4)containing10%sucrose.Sectionswerecut(14um)inacryostatandincubatedat4°CovernightwithAB1783(1:5,000-1:10,000).AfterrinsinginPBSsectionswereincubatedfor60minutesatroomtemperaturewithCy3-conjugatedsecondaryantibodies.AftermountinginamixtureofPBSandglycerol(1:3)containing0.1%p-phenylenediamine,sectionswereexaminedwithaNikonMicrophot-SAepifluorescencemicroscope.



      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidefromthecarboxy-terminusofratGLT-1.
      EpitopeC-terminus
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostGuineaPig
      SpecificityGlialGlutamateTransporterGLT-1(EAAT2).Theantibodyhasbeentestedoncentralnervoussystemtissue.Preabsorptionoftheantiserumwiththeimmunogenpeptide(CatalognumberAG391)completelyabolishestheimmunostaining.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofafamilyofsolutetransporterproteins.Themembrane-boundproteinistheprincipaltransporterthatclearstheexcitatoryneurotransmitterglutamatefromtheextracellularspaceatsynapsesinthecentralnervoussystem.Glutamateclearanceisnecessaryforpropersynapticactivationandtopreventneuronaldamagefromexcessiveactivationofglutamatereceptors.Mutationsinanddecreasedexpressionofthisproteinareassociatedwithamyotrophiclateralsclerosis.Alternativelysplicedtranscriptvariantsofthisgenehavebeendescribed,buttheirfull-lengthnatureisnotknown.
      GeneSymbol
      • SLC1A2
      • GLT-1
      • EAAT2
      • GLT1
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P43004#TransportsL-glutamateandalsoL-andD-aspartate.Essentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium.
      SIZE:574aminoacids;62104Da
      SUBUNIT:Homotrimer.
      SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.
      PTM:Glycosylated.
      SIMILARITY:SwissProt:P43004##Belongstothesodium:dicarboxylate(SDF)symporter(TC2.A.23)family.
      MolecularWeight~62kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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