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Millipore/AB1511 | Anti-Glutamate Decarboxylase 65 & 67 Antibody/AB1511/50 µL
  • Millipore/AB1511 | Anti-Glutamate Decarboxylase 65 & 67 Antibody/AB1511/50 µL

Millipore/AB1511 | Anti-Glutamate Decarboxylase 65 & 67 Antibody/AB1511/50 µL

價格: ￥3948.00 市場價: 6580.00
貨號: AB1511
品牌: Millipore
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    • Description
      CatalogueNumberAB1511
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-GlutamateDecarboxylase65&67Antibody
      AlternateNames
      • 65kDaglutamicaciddecarboxylase
      • Glutamatedecarboxylase65kDaisoform
      • Glutamatedecarboxylase-2(pancreas)
      • glutamatedecarboxylase2
      • glutamatedecarboxylase2(pancreaticisletsandbrain,65kD)
      • glutamatedecarboxylase2(pancreaticisletsandbrain,65kDa)
      BackgroundInformationGutamicaciddecarboxylase(GAD;E.C.4.1.1.15)istheenzymeresponsIBLefortheconversionofglutamicacidtogamma-aminobutyricacid(GABA),themajorinhibitorytransmitterinhigherbrainregions,andputativeparacrinehormoneinpancreaticislets.TwomolecularformsofGAD(65kDaand67kDa,64%aaidentitybetweenforms)arehighlyconservedandbothformsareexpressedintheCNS,pancreaticisletcells,testis,oviductandovary.Theisoformsareregionallydistributedcytoplasmicallyinthebrainsofratsandmice(Sheikh,S.etal.1999).GAD65isanampiphilic,membrane-anchoredprotein(585a.a.),encodedonhumanchromosome10,andisresponsibleforvesicularGABAproduction.GAD67iscytoplasmic(594a.a.),encodedonchromosome2,andseemstoberesponsibleforsignificantcytoplasmicGABAproduction.GADexpressionchangesduringneuraldevelopmentinratspinalcord.ColocalizationofthetwoGADisoformsalsoshowschangesinGAD65/GAD67distributionscorrelatedwithcertaindiseasestatessuchasIDDMandSMS.
      ProductInformation
      FormatPurified
      Control
      • Wholeratbrainlysate,mousebraincellextract.
      PresentationPurifiedrabbitpolyclonalinbuffercontainingPBS-BSAcontaining0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cinundilutedaliquots(notlessthan10μL)fromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationThisAnti-GlutamateDecarboxylase65&67AntibodyisvalidatedforuseinIH,WBforthedetectionofGlutamateDecarboxylase65&67.
      KeyApplications
      • Immunohistochemistry
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:
      1:200-1:5,000dilutionofapreviouslotwasusedinimmunohistochemistry(overnightPAPorABC).Severalfixativesolutionsmaybeused.Aldehyde-combinationfixatives(i.e.thosecontainingformaldehydeandglutaraldehyde)usuallygivesatisfactoryresults.BouinandSusafixativescontaining0.1-0.2%glutaraldehydehavebeenusedsatisfactorily.Alsoreactiveonparaffinembeddedtissue.Proteasedigestionisnotrequired.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenAsyntheticpeptidewiththeaminoacidsequence[C]DFLIEEIERLGQDLfromratglutamatedecarboxylase(GAD65;C-terminusresidues[Cys]+572-585)(1).
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityGlutamateDecarboxylase(GAD65andGAD67).
      Westernblotrevealsadoubletatapproximately65/68kDa.
      Immunohistochemicalstainingcanbeabolishedbypreincubationwith1-10μgpeptide(CatalogNumberAG252)permLofdilutedantibody.
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      • Feline
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesoneofseveralformsofglutamicaciddecarboxylase,identifiedasamajorautoantigenininsulin-dependentdiabetes.Theenzymeencodedisresponsibleforcatalyzingtheproductionofgamma-aminobutyricacidfromL-glutamicacid.ApathogenicroleforthisenzymehasbeenidentifiedinthehumanpancreassinceithasbeenidentifiedasanautoantibodyandanautoreactiveTcelltargetininsulin-dependentdiabetes.Thisgenemayalsoplayaroleinthestiffmansyndrome.
      GeneSymbol
      • GAD2
      • MGC161607
      • GAD65
      • MGC161605
      • GAD-65
      PurificationMethodAmmoniumSulfatePrecipitation
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q05329#CatalyzestheproductionofGABA.
      COFACTOR:Pyridoxalphosphate.
      SIZE:585aminoacids;65411Da
      SUBUNIT:Homodimer(Bysimilarity).
      SUBCELLULARLOCATION:Cytoplasm,cytosol.Cytoplasmicvesicle.Celljunction,synapse,presynapticcellmembrane;Lipid-anchor.Golgiapparatusmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Associatedtocytoplasmicvesicles.Inneurons,cytosolicleafletofGolgimembranesandpresynapticclusters.
      PTM:Phosphorylated;whichdoesnotaffectkineticparametersorsubcellularlocation.&Palmitoylated;whichisrequiredforpresynapticclustering.
      SIMILARITY:SwissProt:Q05329##BelongstothegroupIIdecarboxylasefamily.
      MolecularWeight65/68kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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