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Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk
  • Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

價格: ¥2832.00 市場價: 4720.00

貨號: 15-203
品牌: Millipore
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    • Description
      CatalogueNumber15-203
      TradeName
      • Upstate
      DescriptionAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack
      BackgroundInformationPathwayInvestigatorAntibodyMiniPack:
      EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591).

      AlzheimerPrecursorProteinA4,clone22C11:
      DepositsofamyloidproteininsenileplaquesnearnerveprocessesarefoundinthebrainsofagedhumandandcasesofAlzheimer"sDisease.Theprinciplecomponentofthisextracellularamyloidisbeta/A4,a4kDapeptidederivedfromalargeramyloidprecursorprotein(APP),whichiswidelyexpressedinthebrainandbody.Thecreation,transportandfunctionoftheseproteinsarecurrentlyunderinvestigation.

      14-3-3-eC-Terminus:
      Mammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s.

      The14-3-3epsilon,C-terminalantibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease.

      *Seefullsizeversionsforcorrespondingreferences.
      ProductInformation
      Components
      • MAB348SP-Anti-AmyloidPrecursorProtein,cloneA4;15ug
      • AB9732SP-Anti-14-3-3-eC-terminus;30uL
      • AB9890SP-Anti-AGE;60uL
      Presentation3individualtubescontainingeitherAnti-AlzheimerPrecursorProteinA4,clone22C11;Anti-14-3-3epsilon,C-terminal;orAnti-AGE(AdvancedGlycationEnd-products)
      PropertiesEachvialis30%thesizeoftheparentcatalognumber
      StorageandShippingInformation
      Applications
      ApplicationAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack.
      BIOLOGicalInformation
      CrossReactivityVaries.SeeindividualDataSheets
      EntrezGeneNumber
      GeneSymbol
      • APP
      • PN-II
      • AD1
      • ABETA
      • CTFgamma
      • APPI
      • ABPP
      • A4
      • CVAP
      • PN2
      • PreA4
      • AAA
      • YWHAE
      • KCIP-1
      • MDS
      • 14-3-3E
      • MDCR
      • FLJ45465
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62258#Adapterproteinimplicatedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.Bindstoalargenumberofpartners,usuallybyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner.
      SIZE:255aminoacids;29174Da
      SUBUNIT:Homodimer.InteractswithNDEL1(Bysimilarity).InteractswithHCVcoreprotein.
      SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.
      SIMILARITY:SwissProt:P62258##Belongstothe14-3-3family.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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