Content:2mgOverview
Stem
MACS?A83-01isapotentinhibitorofTGF-βtypeIreceptorsignaling.
Details
Backgroundinformation
StemMACS?A83-01isapotentinhibitoroftheTGF-beta,ActivinandNodalsignalingpathway.A83-01inhibitstheactivinreceptorlikekinasesALK4,ALK5,andALK7therebypreventingthephorphorylationoftheirdownstreamtargetsSMAD2andSMAD3.A83-01canbeusedinsteadofSB431542andismorepotentininhibitiontowardsAKL4,ALK5,andALK7withIC50valuesof45,12,and7.5nMrespectively.A83-01exhibitsonlyweakinhibitionoftherelatedkinasesALK1,ALK2,ALK3,andALK6intheBMPsignalingpathway.