Clone97C5recognizesthehumanCD10antigen,thehumancommonacutelymphoblasticleukemiaantigen(CALLA).CD10isa100kDacellsurfacemoleculeidenticaltohumanmembrane-associatedneutralendopeptidase(NEP)andalsoknownasneprilysinorenkephalinase.HumanCD10isexpressedonawidevarietyofnormalandneoplasticcelltypesfromdifferenttissuesincludingneuralandhematopoieticcells.Itisexpressedonpre–andpro–BcellsandisinvolvedinBcelldevelopmentanddifferentiation.Theantigenisalsopresentonmatureneutrophils,Tcellprecursors,andsomeTcellleukemias/lymphomas.Fur
Thermore,CD10isexpressedonneoplasticcellsofseveralBlymphoidleukemias/lymphomas.