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Millipore/09-843 | Anti-SIRT2 Antibody/09-843/100 µg
  • Millipore/09-843 | Anti-SIRT2 Antibody/09-843/100 µg

Millipore/09-843 | Anti-SIRT2 Antibody/09-843/100 µg

價格: ￥4680.00 市場價: 7800.00
貨號: 09-843
品牌: Millipore
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    • Description
      CatalogueNumber09-843
      Replaces04-1124
      DescriptionAnti-SIRT2Antibody
      AlternateNames
      • SIR2-likeprotein2
      • silencinginformationregulator2-like
      • silentinformationregulator2
      • sir2-relatedproteintype2
      • sirtuin(silentmatingtypeinformationregulation2
      • homolog)2(S.cerevisiae)
        sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)2
      • sirtuin2
      • sirtuintype2
      BackgroundInformationSirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Mammalshavesevensirtuins;SIRT1andSIRT2occupythecytoplasm.SIRT2isaNAD-dependentdeacytylase.Ithasbeenshowntocontrolgenesilencing,cellcycle,andDNAdamagerepair.Inadditon,SIRT2actsasatumorsuppressorinhumangliomaswhichsuggeststhattheectopicexpressionofSIRT2upsetsthemicrotubulenetwork.
      ProductInformation
      FormatAffinityPurified
      Control
      • Humanbraintissuelysate
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationUseAnti-SIRT2Antibody(RabbitPolyclonalAntibody)validatedinWB,IPtodetectSIRT2alsoknownasSIR2-likeprotein2,silentinformationregulator2,sirtuin2.
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      ApplicationNotesWesternBlot(SNAPID)Analysis:0.25μg/mLfromarepresentativelotdetectedSIRT2on10μgofhumanbraintissuelysate.

      ImmunoprecipitationAnalysis:5μgfromarepresentativelotimmunoprecipitatedSIRT2inhumanbrainlysate.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtothematureproteinofhumanSIRT2.
      EpitopeMatureprotein
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesthematureproteinofSIRT2.
      SpeciesReactivity
      • Human
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twotranscriptvariantsresultfromalternativesplicingofthisgene.
      GeneSymbol
      • SIR2
      • SIR2-like
      • SIR2L
      • SIR2L2
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentdeacetylase,whichdeacetylatesthe"Lys-40"ofalpha-tubulin.Involvedinthecontrolofmitoticexitinthecellcycle,probablyviaitsroleintheregulationofCytoskeleton.DespitesomeABIlitytodeacetylatehistonesinvitro,itisunlikelyinvivo.

      CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.

      COFACTOR:Binds1zincionpersubunit.

      ENZYMEREGULATION:InhibitedbySirtinol,A3andM15smallmolecules.Inhibitedbynicotinamide.

      SUBUNITSTRUCTURE:InteractswithHDAC6,suggestingthattheseproteinsbelongtoalargecomplexthatdeacetylatethecytoskeleton.

      SUBCELLULARLOCATION:Cytoplasm?cytoskeleton.Note:Colocalizeswithmicrotubules.

      TISSUESPECIFICITY:Widelyexpressed.Highlyexpressedinheart,brainandskeletalmuscle,whileitisweaklyexpressedinplacentaandlung.Down-regulatedinmanygliomassuggestingthatitmayactasatumorsuppressorgeneinhumangliomaspossiblythroughtheregulationofmicrotubulenetwork.

      DEVELOPMENTALSTAGE:Peaksduringmitosis.Aftermitosis,itisprobablydegradedbythe26Sproteasome.

      PTM:PhosphorylatedattheG2/Mtransitionofthecellcycle.

      SEQUENCESIMILARITIES:Belongstothesirtuinfamily.

      Contains1deacetylasesirtuin-typedomain.

      SEQUENCECAUTION:ThesequenceAAF67015.1differsfromthatshown.Reason:Frameshiftatseveralpositions.
      MolecularWeightObservedmolecularweightis~39kDa.Multipleisoformsaround40kDamaybeobserved.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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