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Millipore/09-243 | Anti-phospho JAK2 (Tyr972) Antibody/09-243/100 µg
  • Millipore/09-243 | Anti-phospho JAK2 (Tyr972) Antibody/09-243/100 µg

Millipore/09-243 | Anti-phospho JAK2 (Tyr972) Antibody/09-243/100 µg

價格: ￥3324.00 市場價: 5540.00
貨號: 09-243
品牌: Millipore
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    • Description
      CatalogueNumber09-243
      DescriptionAnti-phosphoJAK2(Tyr972)Antibody
      AlternateNames
      • Januskinase2
      • Januskinase2(aproteintyrosinekinase)
      • tyrosine-proteinkinaseJAK2
      BackgroundInformationJAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.
      ProductInformation
      FormatAffinityPurified
      Control
      • Transfected293TcelllysatetreatedwithSH2B1beta
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-phosphoJAK2(Tyr972)AntibodydetectslevelofphosphoJAK2(Tyr972)&hasbeenpublished&validatedforuseinWB.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternBlotAnalysis:2μg/mLfromapreviouslotdetectedphosphorylatedJAK2(Tyr972)in10μgofpervanadate-treatedL6celllysate.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheproteinkinase2domainofhumanJAK2.
      EpitopeProteinkinase2domain,phosphorylatedatTyr972.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesphosphorylatedJAK2atTyr972.
      SpeciesReactivity
      • Human
      • Rat
      • Horse
      • Opossum
      • Bovine
      • Chimpanzee
      • Pig
      SpeciesReactivityNoteDemonstratedtoreactinhumanandrat.
      Predictedtoreactwithequine,opossum,bovine,chimpanzee,porcine,platypus,andapebasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneproductisaproteintyrosinekinaseinvolvedinaspecificsubsetofcytokinereceptorsignalingpathways.Ithasbeenfoundtobeconstituitivelyassociatedwiththeprolactinreceptorandisrequiredforresponsestogammainterferon.Micethatdonotexpressanactiveproteinforthisgeneexhibitembryoniclethalityassociatedwiththeabsenceofdefinitiveerythropoiesis.[providedbyRefSeq].
      GeneSymbol
      • JAK-2
      • JTK10
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Playsaroleinleptinsignalingandcontrolofbodyweightbysimilarity.Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction.

      CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

      SUBUNITSTRUCTURE:InteractswithSIRPAandSH2B1bysimilarity.InteractswithIL23R,SKB1andSTAM2.

      SUBCELLULARLOCATION:Endomembranesystem;Peripheralmembraneproteinbysimilarity.Note:Whollyintracellular,possIBLymembraneassociatedbysimilarity.

      TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode.

      DOMAIN:Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomainbysimilarity,whilethepresenceofslightdifferencessuggestadifferentrolefordomain1.

      PTM:Leptinpromotesphosphorylationontyrosineresidues,includingphosphorylationonTyr-813bysimilarity.

      INVOLVEMENTINDISEASE:ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.

      DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.

      DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.

      DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.

      DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment.

      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.

      Contains1FERMdomain.

      Contains1proteinkinasedomain.

      Contains1SH2domain.
      MolecularWeight~125kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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