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Millipore/07-213 | Anti-dimethyl-Histone H4 (Arg3) Antibody/07-213/100 µL
  • Millipore/07-213 | Anti-dimethyl-Histone H4 (Arg3) Antibody/07-213/100 µL

Millipore/07-213 | Anti-dimethyl-Histone H4 (Arg3) Antibody/07-213/100 µL

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貨號: 07-213
品牌: Millipore
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    • Description
      CatalogueNumber07-213
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-dimethyl-HistoneH4(Arg3)Antibody
      AlternateNames
      • H4histonefamily,memberA
      • histone1
      • H4a
      • histonecluster1
      • H4a
      BackgroundInformationHistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs).
      ProductInformation
      FormatAffinityPurified
      Control
      • AcidextractedproteinsfromHeLacells.
      PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining70%storagebuffer0.2MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide,5mg/mLBSAand30%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearatfromdateofreceipt.
      Applications
      ApplicationAnti-dimethyl-HistoneH4(Arg3)AntibodyisaRabbitPolyclonalAntibodyfordetectionofdimethyl-HistoneH4(Arg3)alsoknownasH4histonefamilymemberA,histone1H4a&hasbeenvalidatedinWB.
      KeyApplications
      • WesternBlotting
      ApplicationNotesMethylation/WesternBlotAssay:ReportedbyanindependentlaboratorytodetectHistoneH4methylatedinvitrobyrecombinantPRMT1anddetectedbywesternblotanalysis.
      BIOLOGicalInformation
      ImmunogenBSA-conjugatedsyntheticpeptide(SG[me2R]GKGGKG-C)correspondingtoaminoacids1-9ofHistoneH4withaC-terminalcysteineaddedtofacilitateconjugation.TheimmunizingsequenceisconservedfromTetrahymenatohuman.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesmethylatedHistoneH4(Arg3),MW10kDa.Additionof0.1%Tween?-20inwesternblotbuffersresultsinthedetectionofadditionalproteinsat17kDa(possIBLymethylatedHistoneH2a),34kDaand80kDa.SpecificitydemonstratedbyELISAusingmethylatedandunmethylatedHistoneH4peptides.TheantibodydoesnotdetectrecombinantHistoneH3purifiedfromE.coli.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Vertebrates
      • Invertebrates
      SpeciesReactivityNoteHuman.Broadspeciescross-reactivityisexpected.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Methylation
      PurificationMethodImmunoaffinityChromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:103aminoacids;11367Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
      MolecularWeight10kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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