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Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg
  • Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg

Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg

價格: ￥3444.00 市場價: 5740.00
貨號: 07-1420
品牌: Millipore
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    • Description
      CatalogueNumber07-1420
      ReplacesAB2142P
      DescriptionAnti-VEGFAntibody
      AlternateNames
      • VascularpermeABIlityfactor
      BackgroundInformationVEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.VEGFinducesangiogenesisaswellaspermeabilizationofbloodvessels,andplaysacentralroleintheregulationofvasculogenesis.VEGFexpressioncorrelatestothedegreeoftumorvascularizationandwithincreasedmetastaticrisk.Additionally,VEGFinducesendothelialcellproliferation,promotescellmigration,andinhibitsapoptosis.Consequently,inhibitionofVEGFsignalingabrogatesthedevelopmentofawidevarietyoftumors.
      ProductInformation
      FormatAffinityPurified
      Control
      • Huveccelllysate
      PresentationAffinitypurifiedrabbitpolyclonalIgGemployingimmobilizedmouseVEGFmatrix.Antibodysolution(1mg/ml)waslyophilizedfromPBS,pH7.2.Reconstitutewithsteriledistilledwater.
      StorageandShippingInformation
      StorageConditionsReconstitutedantibody,ataconcentrationof≥0.2mg/mL,isstableforatleastsixweeksat2-8oC.Aliquotsstoredat-20oCarestableforatleastoneyearfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-VEGFAntibodydetectslevelofVEGF&hasbeenpublished&validatedforuseinWB,IH(P),ELISA.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      • ELISA
      ApplicationNotesImmunohistochemisty(paraffin):VEGFstaininginmouseplacenta,tissuewaspretreatedwithcitratebuffer,pH6.0.Apreviouslotofantibodywasdilutedto1:100,usingIHC-Select?detectionwithHRP-DAB.

      Neutralization:Toyieldone-halfmaximalinhibition[ND50]ofthebiologicalactivityofmouseVEGF(50.0ng/mL),aconcentrationof1.0-2.0μg/mLofapreviouslotofthisantibodywasrequired.

      ELISA:Aconcentrationofatleast0.5μg/mL(100μL/well)isrequiredtodetect0.2-0.4ng/wellofrecombinantmouseVEGFusingapreviouslotofthisantibody.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BiologicalInformation
      ImmunogenHighlypure(>98%)recombinantmouseVascularEndothelialGrowthFactor.
      HostRabbit
      SpecificityRecognizesVascularEndothelialGrowthFactor(VEGF),asecretedhomodimericproteinsecretedbyavarietyofvascularizedtissues.ThereportedactivitiesofVEGFincludestimulationofendothelialcellgrowth,angiogenesis,andcapillarypermeability.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.[providedbyRefSeq].
      GeneSymbol
      • VEGFA
      • VPF
      • VEGF-A
      • VEGF
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.
      SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity).
      SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin.
      ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing.
      MolecularWeight27kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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