UniProtSummary | FUNCTION:SwissProt:Q92558#DownstreameffectormoleculesinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactincytoskeleton. SIZE:559aminoacids;61652Da SUBUNIT:ComponentoftheWAVE1complexcomposedofABI2,CYFIP2,C3orf10/HSPC300,NCKAP1andWASF1/WAVE1.CYFIP2bindstoactivatedRAC1whichcausesthecomplextodissociate,releasingactivatedWASF1.ThecomplexcanalsobeactivatedbyNCK1(Bysimilarity).BindsactinandtheArp2/3complex.InteractswithBAIAP2. SUBCELLULARLOCATION:Cytoplasm,cytoskeleton.Note=Dot-likepatterninthecytoplasm.ConcentratedinRac-regulatedmembrane-rufflingareas. TISSUESPECIFICITY:Highlyexpressedinbrain.Lowlyexpressedintestis,ovary,colon,kidney,pancreas,thymus,smallintestineandperipheralblood. DOMAIN:SwissProt:Q92558BindstheArp2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain. SIMILARITY:Contains1WH2domain. |