BackgroundInformation | TheJanusfamilyoftyrosinekinases(JAK)includesJAK1,JAK2,JAK3andTyk2.Thisfamilyassociateswithavarietyofcytokinereceptorsandisactivatedbyligandbinding.Uponligandbindingtocytokinereceptors,JAKsphosphorylatethemselvesandtheirassociatedreceptors.ThisprovidesmultiplebindingsitesforsignalingproteinscontainingSH2orotherphospho-tyrosine-bindingdomains,includingSTATs,Shc,insulinreceptorsubstratesandFAK. |