Immunogen | N-terminal6His-taggedrecombinantfulllengthhumanGSK3β |
Host | Rabbit |
Specificity | GSK3alphaandbeta |
Isotype | IgG |
SpeciesReactivity | |
SpeciesReactivityNote | Predictedtocross-reactwithratbasedonsequencehomology |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscriptionfactors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001)}).[suppliedbyOMIM] |
GeneSymbol | |
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity). SIZE:483aminoacids;50981Da SUBUNIT:Monomer(Bysimilarity). SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1proteinkinasedomain. |
MolecularWeight | Mr46kDa(beta)and51kDa(alpha) |